Epicardial and Pericardial Adiposity Without Myocardial Steatosis in Cushing Syndrome

Cardiovascular disease is the leading cause of death in patients with Cushing syndrome. Cortisol excess and adverse metabolic profile could increase cardiac fat, which can subsequently impair cardiac structure and function. We aimed to evaluate cardiac fat mass and distribution in patients with Cush...

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Published in:The journal of clinical endocrinology and metabolism 2021-12, Vol.106 (12), p.3505-3514
Main Authors: Wolf, Peter, Marty, Benjamin, Bouazizi, Khaoula, Kachenoura, Nadjia, Piedvache, Céline, Blanchard, Anne, Salenave, Sylvie, Prigent, Mikaël, Jublanc, Christel, Ajzenberg, Christiane, Droumaguet, Céline, Young, Jacques, Lecoq, Anne-Lise, Kuhn, Emmanuelle, Agostini, Helene, Trabado, Severine, Carlier, Pierre G, Fève, Bruno, Redheuil, Alban, Chanson, Philippe, Kamenický, Peter
Format: Article
Language:English
Subjects:
Adiposity
Adult
Biomarkers - analysis
Blood Glucose - analysis
Body Mass Index
Cardiomyopathies - epidemiology
Cardiomyopathies - pathology
Cardiovascular diseases
Case-Control Studies
Corticosteroids
Cross-Sectional Studies
Cushing syndrome
Cushing Syndrome - physiopathology
Dextrose
Female
Follow-Up Studies
Glucose
Glycated Hemoglobin A - analysis
Glycosylated hemoglobin
Humans
Intra-Abdominal Fat - pathology
Life Sciences
Male
Medical research
Medicine, Experimental
Middle Aged
Myocardium - pathology
Nuclear magnetic resonance spectroscopy
Pericardium - pathology
Prognosis
Prospective Studies
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Summary:Cardiovascular disease is the leading cause of death in patients with Cushing syndrome. Cortisol excess and adverse metabolic profile could increase cardiac fat, which can subsequently impair cardiac structure and function. We aimed to evaluate cardiac fat mass and distribution in patients with Cushing syndrome. In this prospective, cross-sectional study, 23 patients with Cushing syndrome and 27 control individuals of comparable age, sex, and body mass index were investigated by cardiac magnetic resonance imaging and proton spectroscopy. Patients were explored before and after biochemical disease remission. Myocardial fat measured by the Dixon method was the main outcome measure. The intramyocardial triglyceride/water ratio measured by spectroscopy and epicardial and pericardial fat volumes were secondary outcome measures. No difference was found between patients and controls in intramyocardial lipid content. Epicardial fat mass was increased in patients compared to controls (30.8 g/m2 [20.4-34.8] vs 17.2 g/m2 [13.1-23.5], P 
ISSN:0021-972X
1945-7197
DOI:10.1210/clinem/dgab556