Is the “lactormone” a key-factor for exercise-related neuroplasticity? A hypothesis based on an alternative lactate neurobiological pathway

For many years lactate was seen as a metabolite from glucose metabolism. However, since the last century researchers have shown that this molecule has an important role on liver, muscle, and brain metabolism. Lactate traffics along whole body mediating many biological processes depending on specific...

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Bibliographic Details
Published in:Medical hypotheses 2019-02, Vol.123, p.63-66
Main Authors: Sobral-Monteiro-Junior, Renato, Maillot, Pauline, Gatica-Rojas, Valeska, Ávila, Waldney Roberto M., de Paula, Alfredo M. Batista, Guimarães, André Luiz S., Santos, Sérgio Henrique S., Pupe, Camila Castelo Branco, Deslandes, Andréa Camaz
Format: Article
Language:English
Subjects:
Cognitive science
Humanities and Social Sciences
Metabolism
Neuroplasticity
Neuroscience
Physical activity
Psychology
Pyruvate
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Summary:For many years lactate was seen as a metabolite from glucose metabolism. However, since the last century researchers have shown that this molecule has an important role on liver, muscle, and brain metabolism. Lactate traffics along whole body mediating many biological processes depending on specific situations. For example, glucose is the main substrate used during exercise but lactate released by striated skeletal muscle is used by own muscle as secondary fuel. On the other hand, neuronal firing in the brain is almost totally lactate-dependent. In addition, lactate has an important role on BDNF-mediated neuroplasticity. As this molecule has a pleiotropic role in the body, it was called as “lactormone” in 2009. Here we show basic concepts on peripheral and central metabolism and discuss neurobiological pathways of lactate, including an alternative hypothesis on lactate released during exercise.
ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2018.12.013