The optic nerve sheath diameter as a useful tool for early prediction of outcome after cardiac arrest: A prospective pilot study

• Published in: Resuscitation 2016-06, Vol.103, p.7-13
• Main Authors: Chelly, Jonathan, Deye, Nicolas, Guichard, Jean-Pierre, Vodovar, Dominique, Vong, Ly, Jochmans, Sebastien, Thieulot-Rolin, Nathalie, Sy, Oumar, Serbource-Goguel, Jean, Vinsonneau, Christophe, Megarbane, Bruno, Vivien, Benoit, Tazarourte, Karim, Monchi, Merhan
• Format: Article
• Language: English
• Subjects: Aged; Brain - diagnostic imaging; Cardiac arrest; Cardiology and cardiovascular system; Cardiopulmonary Resuscitation; Emergency; Emerging diseases; Female; Heart Arrest - mortality; Heart Arrest - therapy; Hospital Mortality; Hospitalization; Human health and pathology; Humans; Hypothermia, Induced; Infectious diseases; Intensive Care Units; Life Sciences; Male; Middle Aged; Myelin Sheath - pathology; Neuroprognostication; Optic Nerve - diagnostic imaging; Optic Nerve - pathology; Optic nerve sheath diameter; Outcome; Pilot Projects; Point-of-Care Testing; Prospective Studies; Pulmonology and respiratory tract; Sensitivity and Specificity; Statistics, Nonparametric; Time Factors; Tomography, X-Ray Computed; Toxicology; Ultrasonography
• ISSN: 0300-9572; 1873-1570
• DOI: 10.1016/j.resuscitation.2016.03.006

Abstract Introduction Optic nerve sheath diameter (ONSD) measurement could detect increased intracranial pressure, and might predict outcome in post-cardiac arrest (CA) patients. We assessed the ability of bedside ONSD ultrasonographic measurement performed within day 1 after CA occurrence to predict in-hospital survival in patients treated with therapeutic hypothermia (TH). Methods In two French ICUs, a prospective study included all consecutive patients with CA without traumatic or neurological etiology, successfully resuscitated and TH-treated. ONSD measurements were performed on day 1, 2, and 3 (ONSD1, 2, 3 respectively) after return of spontaneous circulation. All records were registered according to Utstein style. Results ONSD1, 2, 3 were assessed in 36, 21, and 14 patients respectively. 19/36 patients (53%) were discharged alive from hospital, including 14/36 (39%) with favorable neurological outcome (Cerebral Performance Category [CPC] score 1–2). Survivors and non-survivors were similar regarding age, sex, cardiovascular risk factors, location and etiology of CA, simplified acute physiology score II, occurrence of post-CA shock, and clinical parameters collected during ONSD measurements. Median ONSD1 was significantly larger in non-survivors versus survivors (7.2 mm [interquartile: 6.8–7.4] versus 6.5 mm [interquartile: 6.0–6.8]; p = 0.008). After adjustment on predictive factors, ONSD1 was significantly associated with in-hospital mortality (OR 6.3; 95%CI [1.05–40] per mm of ONSD1 above 5.5 mm; p = 0.03), and CPC score (OR for 1 point increase in CPC score: 3.2; 95%CI [1.2–9.4] per mm of ONSD1 above 5.5 mm; p = 0.03). ONSD1 was significantly correlated with brain edema assessed by the cerebrum gray matter attenuation to white matter attenuation ratio, measured by the brain computed tomography scan performed on admission in 20 patients (Spearman rho = −0.5, p = 0.04). Conclusions ONSD seems a promising tool to early assess outcome in post-CA patients treated with TH.