Interest of the faecal and plasma matrix for monitoring the exposure of wildlife or domestic animals to anticoagulant rodenticides

Anticoagulant rodenticides (ARs), particularly second-generation compounds (SGAR), are known to be a potential threat to unintended species due to their tissue persistence. The liver is the storage tissue of ARs and is a matrix of choice in diagnosing exposure and intoxication of non-target fauna. H...

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Published in:Environmental toxicology and pharmacology 2023-01, Vol.97, p.104033, Article 104033
Main Authors: Rached, Antoine, Mahjoub, Tarek, Fafournoux, Ambre, Barbier, Brigitte, Fourel, Isabelle, Caruel, Hervé, Lefebvre, Sébastien, Lattard, Virginie
Format: Article
Language:English
Subjects:
Animal biology
Animals
Animals, Domestic
Animals, Wild
Anticoagulant rodenticides
Anticoagulants - toxicity
Biochemistry
Biochemistry, Molecular Biology
Biological matrix
Ecotoxicology
Environmental Monitoring
Exposure
Faeces
Feces - chemistry
Food and Nutrition
Life Sciences
Liver
Plasma
Rodenticides - toxicity
Toxicology
Toxicology and food chain
Veterinary medicine and animal Health
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Summary:Anticoagulant rodenticides (ARs), particularly second-generation compounds (SGAR), are known to be a potential threat to unintended species due to their tissue persistence. The liver is the storage tissue of ARs and is a matrix of choice in diagnosing exposure and intoxication of non-target fauna. However, it is only available on dead animals. Blood and faeces can be used on living animals. These two biological matrices were compared in terms of their relevance to exposure to ARs. In addressing this question, we compared the faecal, plasma and liver concentrations of bromadiolone, one of the SGAR frequently implicated in wildlife exposure. We studied this comparison at the individual level and at the population level, considering three influencing factors: dose, sex and time. Our findings demonstrate that faecal analyses are more valuable than plasma analyses for monitoring AR exposure of domestic and wild animals, even if faecal concentrations cannot be correlated with liver concentrations. •Fecal matrix is more relevant than plasma matrix for AR exposure assessment.•AR exposure assessment based on plasma generates more false negatives.•Liver AR concentrations are not extropolable from fecal concentrations.•Dating the exposure might be approximated by the isomeric composition of residues.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2022.104033