Thermodynamic studies of mixtures for topical anesthesia: Lidocaine–salol binary phase diagram

The lidocaine–salol binary system has been investigated by differential scanning calorimetry, direct visual observations, and X-ray powder diffraction, resulting in a temperature-composition phase diagram with a eutectic equilibrium. The eutectic mixture, found at 0.423 ± 0.007 lidocaine mole-fracti...

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Bibliographic Details
Published in:Thermochimica acta 2010-01, Vol.497 (1), p.124-128
Main Authors: Lazerges, Mathieu, Rietveld, Ivo B., Corvis, Yohann, Céolin, René, Espeau, Philippe
Format: Article
Language:English
Subjects:
Anesthetics. Neuromuscular blocking agents
Antiarythmic agents
Anticonvulsants. Antiepileptics. Antiparkinson agents
Biological and medical sciences
Cardiovascular system
Chemical Sciences
Chemistry
EMLA
Eutectic mixtures
Exact sciences and technology
General and physical chemistry
Lidocaine
Liquid-solid equilibria
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Phase diagram
Phase equilibria
Salol
Topical anesthesia
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Summary:The lidocaine–salol binary system has been investigated by differential scanning calorimetry, direct visual observations, and X-ray powder diffraction, resulting in a temperature-composition phase diagram with a eutectic equilibrium. The eutectic mixture, found at 0.423 ± 0.007 lidocaine mole-fraction, melts at 18.2 ± 0.5 °C with an enthalpy of 17.3 ± 0.5 kJ mol −1. This indicates that the liquid phase around the eutectic composition is stable at room temperature. Moreover, the undercooled liquid mixture does not easily crystallize. The present binary mixture exhibits eutectic behavior similar to the prilocaine–lidocaine mixture in the widely used EMLA ® topical anesthetic preparation.
ISSN:0040-6031
1872-762X
DOI:10.1016/j.tca.2009.08.016