A physical map of human chromosome 14

We report the construction of a tiling path of around 650 clones covering more than 99% of human chromosome 14. Clone overlap information to assemble the map was derived by comparing fully sequenced clones with a database of clone end sequences (sequence tag connector strategy). We selected homogene...

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Published in:Nature (London) 2001-02, Vol.409 (6822), p.947-948
Main Authors: Heilig, Roland, Brüls, Thomas, Gyapay, Gabor, Petit, Jean-Louis, Artiguenave, François, Vico, Virginie, Qin, Shizen, Tin-Wollam, Aye Mon, Da Silva, Corinne, Muselet, Delphine, Mavel, Delphine, Pelletier, Eric, Levy, Michael, Fujiyama, Asao, Matsuda, Fumihiko, Wilson, Richard, Rowen, Lee, Hood, Leroy, Weissenbach, Jean, Saurin, William
Format: Article
Language:English
Subjects:
Bacteria
chromosome 14
Chromosomes
Chromosomes, Artificial, Bacterial
Chromosomes, Human, Pair 14
Cloning
Cloning, Molecular
Connectors
Continuity
Deoxyribonucleic acid
DNA
Escherichia coli
Genes
Genomics
Human
Humanities and Social Sciences
Humans
letters-to-nature
Life Sciences
multidisciplinary
Physical Chromosome Mapping
Radiation Hybrid Mapping
Science
Seeds
Sequence Tagged Sites
Strategy
Tiling
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cited_by cdi_FETCH-LOGICAL-c733t-e802b70dac9625d68a8a6c47f96e8e5ae182da69739be8b6812a84724c3f49563
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container_end_page 948
container_issue 6822
container_start_page 947
container_title Nature (London)
container_volume 409
creator Heilig, Roland
Brüls, Thomas
Gyapay, Gabor
Petit, Jean-Louis
Artiguenave, François
Vico, Virginie
Qin, Shizen
Tin-Wollam, Aye Mon
Da Silva, Corinne
Muselet, Delphine
Mavel, Delphine
Pelletier, Eric
Levy, Michael
Fujiyama, Asao
Matsuda, Fumihiko
Wilson, Richard
Rowen, Lee
Hood, Leroy
Weissenbach, Jean
Saurin, William
description We report the construction of a tiling path of around 650 clones covering more than 99% of human chromosome 14. Clone overlap information to assemble the map was derived by comparing fully sequenced clones with a database of clone end sequences (sequence tag connector strategy). We selected homogeneously distributed seed points using an auxiliary high-resolution radiation hybrid map comprising 1,895 distinct positions. The high long-range continuity and low redundancy of the tiling path indicates that the sequence tag connector approach compares favourably with alternative mapping strategies.
doi_str_mv 10.1038/35057177
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identifier ISSN: 0028-0836
ispartof Nature (London), 2001-02, Vol.409 (6822), p.947-948
issn 0028-0836
1476-4687
language eng
recordid cdi_hal_primary_oai_HAL_hal_04312835v1
source Springer Nature - Connect here FIRST to enable access
subjects Bacteria
chromosome 14
Chromosomes
Chromosomes, Artificial, Bacterial
Chromosomes, Human, Pair 14
Cloning
Cloning, Molecular
Connectors
Continuity
Deoxyribonucleic acid
DNA
Escherichia coli
Genes
Genomics
Human
Humanities and Social Sciences
Humans
letters-to-nature
Life Sciences
multidisciplinary
Physical Chromosome Mapping
Radiation Hybrid Mapping
Science
Seeds
Sequence Tagged Sites
Strategy
Tiling
title A physical map of human chromosome 14
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