Metabolomic profiles of 38 acylcarnitines in major depressive episodes before and after treatment

Major depression is associated with changes in plasma L-carnitine and acetyl-L-carnitine. But its association with acylcarnitines remains unclear. The aim of this study was to assess metabolomic profiles of 38 acylcarnitines in patients with major depression before and after treatment compared to he...

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Published in:Psychological medicine 2024-01, Vol.54 (2), p.289-298
Main Authors: Ait Tayeb, Abd El Kader, Colle, Romain, Chappell, Kenneth, El-Asmar, Khalil, Acquaviva-Bourdain, Cécile, David, Denis J, Trabado, Séverine, Chanson, Philippe, Feve, Bruno, Becquemont, Laurent, Verstuyft, Céline, Corruble, Emmanuelle
Format: Article
Language:English
Subjects:
Acetyl-L-carnitine
Alzheimer's disease
Antidepressants
Body mass index
Carnitine
Endocrinology and metabolism
Fatty acids
Health care
Human health and pathology
Life Sciences
Liquid chromatography
Mass spectroscopy
Mental depression
Mental disorders
Metabolites
Metabolomics
Plasma
Psychiatrists
Psychosis
Psychotropic drugs
Remission (Medicine)
Serotonin
Software
Spectrometry
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Summary:Major depression is associated with changes in plasma L-carnitine and acetyl-L-carnitine. But its association with acylcarnitines remains unclear. The aim of this study was to assess metabolomic profiles of 38 acylcarnitines in patients with major depression before and after treatment compared to healthy controls (HCs). Metabolomic profiles of 38 plasma short-, medium-, and long-chain acylcarnitines were performed by liquid chromatography-mass spectrometry in 893 HCs from the VARIETE cohort and 460 depressed patients from the METADAP cohort before and after 6 months of antidepressant treatment. As compared to HCs, depressed patients had lower levels of medium- and long-chain acylcarnitines. After 6 months of treatment, increased levels of medium- and long-chain acyl-carnitines were observed that no longer differed from those of controls. Accordingly, several medium- and long-chain acylcarnitines were negatively correlated with depression severity. These medium- and long-chain acylcarnitine dysregulations argue for mitochondrial dysfunction through fatty acid -oxidation impairment during major depression.
ISSN:0033-2917
1469-8978
DOI:10.1017/S003329172300140X