Effects of short-term corticoid ingestion on food intake and adipokines in healthy recreationally trained men

• Published in: European journal of applied physiology 2009-01, Vol.105 (2), p.309-313
• Main Authors: Rieth, N., Jollin, L., Le Panse, B., Lecoq, A.-M., Arlettaz, A., De Ceaurriz, J., Collomp, K.
• Format: Article
• Language: English
• Subjects: Adiponectin - blood; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Blood Glucose; Body composition; Body Composition - drug effects; Body fat; Body Weight - drug effects; Cross-Over Studies; Diet; Double-Blind Method; Eating - drug effects; Food; Fundamental and applied biological sciences. Psychology; Glucose; Human Physiology; Humans; Insulin - blood; Insulin resistance; Leptin - blood; Life Sciences; Male; Metabolism; Obesity; Occupational Medicine/Industrial Medicine; Original Article; Prednisolone - pharmacology; Random Allocation; Software; Sports Medicine; Tumor Necrosis Factor-alpha - blood; Tumor necrosis factor-TNF; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports; Young Adult
• ISSN: 1439-6319; 1439-6327
• DOI: 10.1007/s00421-008-0904-6

In order to test the hypothesis that short-term corticoid intake alters food intake, body composition and adipokines secretion in healthy volunteers with regular sport practice, nutrient intake was assessed in eight male athletes with and without prednisolone (PRED, 60 mg/day for 1 week) ingestion in a random, double blind, crossover design. Body weight, body composition, adipokines (i.e., leptin, adiponectin and TNF-α), insulin and blood glucose were determined before and at the end of each treatment. PRED did not induce any significant change in body weight, body composition or food intake. Insulin and TNF-α were not significantly altered with PRED compared to placebo but blood glucose, leptin and adiponectin concentrations at rest appear significantly increased after PRED treatment ( P