Long-term follow-up of high-risk neuroblastoma survivors treated with high-dose chemotherapy and stem cell transplantation rescue

Intensive treatments including high-dose chemotherapy (HDC) with autologous stem cell rescue have improved high-risk neuroblastoma (HRNB) survival. We report the long-term health status of 145 HRNB survivors, alive and disease-free 5 years post HDC. Median follow-up was 15 years (range = 5–34). Six...

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Published in:Bone marrow transplantation (Basingstoke) 2021-08, Vol.56 (8), p.1984-1997
Main Authors: Haghiri, Sandrine, Fayech, Chiraz, Mansouri, Imène, Dufour, Christelle, Pasqualini, Claudia, Bolle, Stéphanie, Rivollet, Sophie, Dumas, Agnès, Boumaraf, Amel, Belhout, Amel, Journy, Neige, Souchard, Vincent, Vu-Bezin, Giao, Veres, Cristina, Haddy, Nadia, De Vathaire, Florent, Valteau-Couanet, Dominique, Fresneau, Brice
Format: Article
Language:English
Subjects:
692/308/174
692/499
692/699/67/2324
692/700/1720
Acute myeloid leukemia
Autografts
Busulfan
Cancer
Care and treatment
Cell Biology
Chemotherapy
Development and progression
Glioma
Growth rate
Hearing loss
Heart diseases
Hematology
Hyperplasia
Internal Medicine
Leukemia
Life Sciences
Medicine
Medicine & Public Health
Melanoma
Methods
Myeloid leukemia
Neoplasia
Neoplasms
Neuroblastoma
Patient outcomes
Public Health
Risk
Santé publique et épidémiologie
Sarcoma
Stem cell transplantation
Stem Cells
Survival
Thyroid
Transplantation
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Summary:Intensive treatments including high-dose chemotherapy (HDC) with autologous stem cell rescue have improved high-risk neuroblastoma (HRNB) survival. We report the long-term health status of 145 HRNB survivors, alive and disease-free 5 years post HDC. Median follow-up was 15 years (range = 5–34). Six patients experienced late relapses, 11 developed second malignant neoplasms (SMNs), and 9 died. Event-free and overall survivals 20 years post HDC were 82% (95% CI = 70%–90%) and 89% (78%–95%), respectively. Compared with the French general population, the standardized mortality ratio was 19 (95% CI = 8.7–36.1; p  
ISSN:0268-3369
1476-5365
DOI:10.1038/s41409-021-01258-1