Synthesis of benzo analogs of oxoarcyriaflavins and caulersine

In the course of a program aimed at designing new antitumor agents, we were interested in the synthesis of mixed structures of maleimidophenyl carbazoles and natural product caulersine as potential CDK inhibitors. This was performed through an efficient four-step sequence starting from indole or 3-f...

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Bibliographic Details
Published in:Tetrahedron 2007-09, Vol.63 (38), p.9465-9475
Main Authors: Bourderioux, Aurélie, Routier, Sylvain, Bénéteau, Valérie, Mérour, Jean-Yves
Format: Article
Language:English
Subjects:
Chemical Sciences
Medicinal Chemistry
Organic chemistry
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Summary:In the course of a program aimed at designing new antitumor agents, we were interested in the synthesis of mixed structures of maleimidophenyl carbazoles and natural product caulersine as potential CDK inhibitors. This was performed through an efficient four-step sequence starting from indole or 3-formyl- N-Boc indole. 5 H-Benzocycloheptaindol-6-one derivatives equipped with a fused maleimide (oxophenylarcyriaflavins) or a methyl ester (benzo analog of caulersine) on the central tropone ring were thus obtained. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2007.06.118