Prospective diagnostic performance of semiconductor SPECT myocardial perfusion imaging: wall thickening analysis reduces the need for an additional prone acquisition

• Published in: European journal of nuclear medicine and molecular imaging 2019-09, Vol.46 (10), p.2042-2050
• Main Authors: Djaileb, Loïc, Dubois, Benjamin, de Leiris, Nicolas, Leenhardt, Julien, Canu, Marjorie, Sy, Olivier Phan, Carabelli, Adrien, Boussat, Bastien, Dumas, Laurent, Broisat, Alexis, Vanzetto, Gérald, Fagret, Daniel, Ghezzi, Catherine, Barone-Rochette, Gilles, Riou, Laurent M.
• Format: Article
• Language: English
• Subjects: Aged; Angiography; Blood vessels; Cardiology; Cardiovascular disease; Coronary artery; Coronary artery disease; Coronary Artery Disease - diagnostic imaging; Diagnostic systems; Electrocardiography; Female; Heart diseases; Humans; Imaging; Life Sciences; Male; Medical diagnosis; Medical imaging; Medicine; Medicine & Public Health; Middle Aged; Myocardial Perfusion Imaging - instrumentation; Myocardial Perfusion Imaging - methods; Myocardial Perfusion Imaging - standards; Nuclear Medicine; Oncology; Original Article; Orthopedics; Patient Positioning - methods; Patient Positioning - standards; Perfusion; Predictive Value of Tests; Prone Position; Radiology; Radiopharmaceuticals; Regional analysis; Semiconductors; Single photon emission computed tomography; Stress; Supine Position; Thallium Radioisotopes; Thickening; Tomography; Tomography, Emission-Computed, Single-Photon - instrumentation; Tomography, Emission-Computed, Single-Photon - methods; Tomography, Emission-Computed, Single-Photon - standards
• ISSN: 1619-7070; 1619-7089
• DOI: 10.1007/s00259-019-04415-3

Purpose To determine whether the assessment of regional wall thickening (WT) in addition to myocardial perfusion from stress supine acquisitions could compensate for the lack of prone acquisition and the corresponding decrease in the diagnostic performance of SPECT myocardial perfusion imaging (MPI) in patients with known or suspected coronary artery disease (CAD). Methods The study group comprised 41 patients (123 vessels) with known or suspected CAD prospectively recruited for systematic prone and supine 201 Tl stress SPECT MPI. The diagnostic performance of SPECT MPI was determined for various image sets including nongated supine images (supine NG), nongated combined prone and supine images (prone and supine NG) and gated supine images, allowing WT evaluation from NG images in addition to perfusion (supine NG + WT) using invasive coronary angiography and fractional flow reserve as the gold standards. Results The rate of false positives was significantly higher among the supine NG images (20.8%) than among either the prone and supine NG or the supine NG + WT images (3.3% and 2.7%, respectively, P