Influence of blood glucose on heart rate and cardiac autonomic function. The DESIR study

• Published in: Diabetic medicine 2011-04, Vol.28 (4), p.440-449
• Main Authors: Valensi, P., Extramiana, F., Lange, C., Cailleau, M., Haggui, A., Maison Blanche, P., Tichet, J., Balkau, B.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Autonomic Nervous System; Autonomic Nervous System - metabolism; Autonomic Nervous System - physiopathology; Biological and medical sciences; Blood Glucose; Blood Glucose - metabolism; diabetes; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; epidemiology; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Glycated Hemoglobin A - metabolism; Heart Rate; Heart Rate - physiology; heart rate recovery; heart rate variability; Hemoglobin A, Glycosylated; Humans; Insulin Resistance; Insulin Resistance - physiology; Life Sciences; Male; Medical sciences; Middle Aged; Santé publique et épidémiologie; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology
• ISSN: 0742-3071; 1464-5491
• DOI: 10.1111/j.1464-5491.2010.03222.x

Diabet. Med. 28, 440–449 (2011) Objectives  To evaluate in a general population, the relationships between dysglycaemia, insulin resistance and metabolic variables, and heart rate, heart rate recovery and heart rate variability. Methods  Four hundred and forty‐seven participants in the Data from an Epidemiological Study on the Insulin Resistance syndrome (DESIR) study were classified according to glycaemic status over the preceding 9 years. All were free of self‐reported cardiac antecedents and were not taking drugs which alter heart rate. During five consecutive periods: rest, deep breathing, recovery, rest and lying to standing, heart rate and heart rate varability were evaluated and compared by ANCOVA and trend tests across glycaemic classes. Spearman correlation coefficients quantified the relations between cardio‐metabolic risk factors, heart rate and heart rate varability. Results  Heart rate differed between glycaemic groups, except during deep breathing. Between rest and deep‐breathing periods, patients with diabetes had a lower increase in heart rate than others (Ptrend