HTLV-2B Strains, Similar to Those Found in Several Amerindian Tribes, Are Endemic in Central African Bakola Pygmies

Background. The presence and origin of endemic foci of human T-lymphotropic virus type 2 (HTLV2) infection in Africa remain a matter of debate. Methods. To better appreciate such determinants, we performed a survey of 1918 inhabitants from Cameroon forest areas, including 1051 Bakola Pygmies and 867...

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Published in:The Journal of infectious diseases 2011-05, Vol.203 (9), p.1316-1323
Main Authors: Mauclère, Philippe, Afonso, Philippe Vicente, Meertens, Laurent, Plancoulaine, Sabine, Calattini, Sara, Froment, Alain, Van Beveren, Monique, de Thé, Guy, Quintana-Murci, Lluis, Mahieux, Renaud, Gessain, Antoine
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cameroon - epidemiology
Child
Child, Preschool
Cluster Analysis
Disease transmission
Endemic Diseases
Female
Fundamental and applied biological sciences. Psychology
HTLV-II Infections - epidemiology
Human T lymphotropic virus 1
Human T lymphotropic virus 2
Human T-lymphotropic virus
Human T-lymphotropic virus 1 - isolation & purification
Human T-lymphotropic virus 2 - genetics
Human T-lymphotropic virus 2 - isolation & purification
Humans
Infections
Infectious diseases
Life Sciences
Male
Medical sciences
Microbiology
Microbiology and Parasitology
Middle Aged
Molecular Epidemiology
Molecular Sequence Data
Phylogenetics
Population Groups
Retroviridae
RNA, Viral - genetics
Sequence Analysis, DNA
Sequence Homology
Seroepidemiologic Studies
T lymphocytes
Terminal Repeat Sequences
Viruses
Young Adult
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Summary:Background. The presence and origin of endemic foci of human T-lymphotropic virus type 2 (HTLV2) infection in Africa remain a matter of debate. Methods. To better appreciate such determinants, we performed a survey of 1918 inhabitants from Cameroon forest areas, including 1051 Bakola Pygmies and 867 Bantus. Results. The overall HTLV-1/2 seroprevalence was 4% (49 cases of HTLV-1 and 27 cases of HTLV-2 infection). Both infections were mainly restricted to the Bakola Pygmies, with surprisingly no HTLV-2 infections in the Bantu population. Both HTLV-1 and HTLV-2 seroprevalences increased with age. There was evidence of ongoing HTLV-2 transmission in this population. Lymphoid T cell lines producing HTLV-2 were established. HTLV-2 long terminal repeat sequences (672 base pairs) obtained from 7 infected Bakola were highly similar to each other (
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jir031