Lack of association between the angiotensin-converting enzyme gene (I/D) polymorphism and diabetic nephropathy in Tunisian type 2 diabetic patients

Objective. The aim of the present study was to investigate whether the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is associated with diabetic nephropathy and type 2 diabetes in the Tunisian population. Design. A case-control study was conducted among 141 unrelated type...

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Published in:Journal of the renin-angiotensin-aldosterone system 2008-03, Vol.9 (1), p.32-36
Main Authors: Arfa, Imen, Abid, Abdelmajid, Nouira, Sonia, Elloumi-Zghal, Houda, Malouche, Dhafer, Mannai, Imen, Zorgati, Mohamed Majdi, Ben Alaya, Nissaf, Rebai, Ahmed, Zouari, Béchir, Ben Ammar, Slim, Ben Rayana, Mohamed Chiheb, Hmida, Slama, Blousa-Chabchoub, Samira, Abdelhak, Sonia
Format: Article
Language:English
Subjects:
Aged
Case-Control Studies
Diabetes Mellitus, Type 2 - genetics
Diabetic Nephropathies - genetics
DNA Transposable Elements
Endocrinology and metabolism
Female
Human health and pathology
Humans
Life Sciences
Male
Middle Aged
Peptidyl-Dipeptidase A - genetics
Polymorphism, Genetic
Sequence Deletion
Tunisia
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Summary:Objective. The aim of the present study was to investigate whether the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is associated with diabetic nephropathy and type 2 diabetes in the Tunisian population. Design. A case-control study was conducted among 141 unrelated type 2 diabetic patients with (90 patients) or without nephropathy (51 patients) and 103 non-diabetic controls with normal fasting blood glucose. Genotyping was performed using a nested polymerase chain reaction amplification in order to identify correctly heterozygous individuals. Results. The distribution of DD, ID and II genotypes did not significantly differ between type 2 diabetic patients with or without nephropathy (DD: 44%; ID: 46%; II: 10% vs. DD: 41%; ID: 47 %; II: 12%, respectively).There was also no significant statistical difference between the genotype distribution and allele frequencies of the (I/D) polymorphism in all type 2 diabetic subjects compared to non-diabetic controls with normal fasting blood glucose (DD: 43%; ID: 46%; II: 11% vs. DD: 37%; ID: 48% ;II: 15%, respectively). Conclusions. In the present preliminary study, the (I/D) polymorphis within the ACE gene is likely not associated with diabetic nephropathy nor with type 2 diabetes in the Tunisian studied population.
ISSN:1470-3203
1752-8976
DOI:10.3317/jraas.2008.002