Reduced Prevalence of Alcoholic Gastritis in Hospitalized Individuals Who Consume Cannabis

Background Alcoholic gastritis, a superficial erosive disease of the stomach, is a common manifestation of risky alcohol use. In contrast, cannabis which is frequently co‐used with alcohol suppresses gastric acidity and might counteract the deleterious effect of alcohol on the gastric mucosa. Howeve...

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Bibliographic Details
Published in:Alcoholism, clinical and experimental research clinical and experimental research, 2019-02, Vol.43 (2), p.270-276
Main Authors: Adejumo, Adeyinka Charles, Li, Jingjing, Akanbi, Olalekan, Adejumo, Kelechi Lauretta, Bukong, Terence Ndonyi
Format: Article
Language:English
Subjects:
Acidity
Acute Alcoholic Gastritis
Adults
Age Factors
Alcohol Drinking - adverse effects
Alcohol Drinking - epidemiology
Alcohol use
Alcoholism
Alcohols
Cannabis
Case-Control Studies
Comorbidity
Drinking behavior
Drug abuse
Drug addiction
Female
Gastric juice
Gastric mucosa
Gastritis
Gastritis - chemically induced
Gastritis - epidemiology
Hospitalization
Human health and pathology
Humans
Legislation
Life Sciences
Male
Marijuana
Marijuana Smoking - epidemiology
Middle Aged
Poisson density functions
Prevalence
Regression analysis
Risk Factors
Risk-Taking
Stomach
United States - epidemiology
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Summary:Background Alcoholic gastritis, a superficial erosive disease of the stomach, is a common manifestation of risky alcohol use. In contrast, cannabis which is frequently co‐used with alcohol suppresses gastric acidity and might counteract the deleterious effect of alcohol on the gastric mucosa. However, no clinical study has examined the impact of cannabis use on the development of alcoholic gastritis among risky alcohol users. Methods We analyzed hospital discharge records of adults (age ≥ 18 years), from 2014 of the Nationwide Inpatient Sample, with a diagnosis of risky alcohol use (n = 316,916). We used a propensity‐based matching algorithm to match cannabis users to nonusers on 1:1 ratio (30,713: 30,713). We then measured the adjusted relative risk (aRR) for having alcoholic gastritis using conditional Poisson regression models with generalized estimating equations. Results Our study revealed that among risky alcohol users, cannabis co‐users have a lower prevalence of alcoholic gastritis compared to noncannabis users (1,289 [1,169 to 1,421] vs. 1,723 [1,583 to 1,875] per 100,000 hospitalizations for risky alcohol use), resulting in a 25% decreased probability of alcoholic gastritis (aRR: 0.75 [0.66 to 0.85]; p‐value
ISSN:0145-6008
1530-0277
DOI:10.1111/acer.13930