Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans

1  Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905; and 2  Department of Medicine, University of Vermont, Burlington, Vermont 05405 A decline in muscle mass and contractile function are prominent features of the sarcopenia of old age. Because myosin heavy chain is an...

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Published in:American journal of physiology: endocrinology and metabolism 1997-10, Vol.273 (4), p.E790-E800
Main Authors: Balagopal, P, Rooyackers, Olav E, Adey, Deborah B, Ades, Philip A, Nair, K. Sreekumaran
Format: Article
Language:English
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Summary:1  Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905; and 2  Department of Medicine, University of Vermont, Burlington, Vermont 05405 A decline in muscle mass and contractile function are prominent features of the sarcopenia of old age. Because myosin heavy chain is an important contractile protein, it was hypothesized that synthesis of this protein decreases in sarcopenia. The fractional synthesis rate of myosin heavy chain was measured simultaneously with rates of mixed muscle and sarcoplasmic proteins from the increment of [ 13 C]leucine in these proteins purified from serial needle biopsy samples taken from 24 subjects (age: from 20 to 92 yr) during a primed continuous infusion of L -[1- 13 C]leucine. A decline in synthesis rate of mixed muscle protein ( P  
ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.1997.273.4.E790