The metabolic consequences of critical illness: acute effects on glutamine and protein metabolism

Departments of 1  Diabetes, Endocrinology and Metabolic Medicine and 2  Intensive Care, St. Thomas' Hospital, London SE1 7EH, United Kingdom Net protein loss and large decreases in plasma glutamine concentration are characteristics of critical illness. We have used [2- 15 N]glutamine and [1- 13...

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Published in:American journal of physiology: endocrinology and metabolism 1999-01, Vol.276 (1), p.E163-E170
Main Authors: Jackson, N. C, Carroll, P. V, Russell-Jones, D. L, Sonksen, P. H, Treacher, D. F, Umpleby, A. M
Format: Article
Language:English
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Summary:Departments of 1  Diabetes, Endocrinology and Metabolic Medicine and 2  Intensive Care, St. Thomas' Hospital, London SE1 7EH, United Kingdom Net protein loss and large decreases in plasma glutamine concentration are characteristics of critical illness. We have used [2- 15 N]glutamine and [1- 13 C]leucine to investigate whole body glutamine and leucine kinetics in a group of critically ill patients and matched healthy controls. Glutamine appearance rate (R a,Gln ) was similar in both groups. However, in the patients, the proportion of R a,Gln arising from protein breakdown was higher than in the control group (43 ± 3   vs. 32 ± 2%, P  
ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.1999.276.1.E163