Effect of stimulation frequency on contraction-induced glucose transport in rat skeletal muscle

1  Copenhagen Muscle Research Centre and 2  Department of Human Physiology, The August Krogh Institute, and 3  Department of Medical Physiology, The Panum Institute, University of Copenhagen, 2200 Copenhagen N, Denmark Previous studies have indicated that frequency of stimulation is a major determin...

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Published in:American journal of physiology: endocrinology and metabolism 2000-10, Vol.279 (4), p.E862-E867
Main Authors: Ihlemann, Jacob, Ploug, Thorkil, Hellsten, Ylva, Galbo, Henrik
Format: Article
Language:English
Subjects:
Adenosine Diphosphate - metabolism
Adenosine Monophosphate - metabolism
Adenosine Triphosphate - metabolism
Adenylate Kinase
Animals
Biological Transport - physiology
Deoxyglucose - pharmacokinetics
Electric Stimulation
Glucose - metabolism
Glycogen - metabolism
In Vitro Techniques
Inosine Monophosphate - metabolism
Lactic Acid - metabolism
Male
Muscle Contraction - physiology
Muscle, Skeletal - metabolism
Phosphocreatine - metabolism
Rats
Rats, Wistar
Reaction Time - physiology
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Summary:1  Copenhagen Muscle Research Centre and 2  Department of Human Physiology, The August Krogh Institute, and 3  Department of Medical Physiology, The Panum Institute, University of Copenhagen, 2200 Copenhagen N, Denmark Previous studies have indicated that frequency of stimulation is a major determinant of glucose transport in contracting muscle. We have now studied whether this is so also when total force development or metabolic rate is kept constant. Incubated soleus muscles were electrically stimulated to perform repeated tetanic contractions at four different frequencies (0.25, 0.5,   1, and 2 Hz) for 10 min. Resting length was adjusted to achieve identical total force development or metabolic rate (glycogen depletion and lactate accumulation). Overall, at constant total force development, glucose transport (2-deoxyglucose uptake) increased with stimulation frequency ( P   0.05) at the two lower (0.25 and 0.5 Hz) as well as at the two higher (1 and 2 Hz) frequencies. Glycogen decreased ( P  
ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.2000.279.4.e862