Gender differences in substrate utilization during submaximal exercise in endurance-trained subjects

Departments of 1  Human Physiology and 2  Medical Physiology, Copenhagen Muscle Research Centre, University of Copenhagen; and 3  Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, DK-2100 Copenhagen, Denmark Substrate utilization across the leg during 90 min of bicycle exercis...

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Published in:American journal of physiology: endocrinology and metabolism 2002-02, Vol.282 (2), p.E435-E447
Main Authors: Roepstorff, Carsten, Steffensen, Charlotte H, Madsen, Marianne, Stallknecht, Bente, Kanstrup, Inge-Lis, Richter, Erik A, Kiens, Bente
Format: Article
Language:English
Subjects:
Adult
Bicycling
Blood Glucose - metabolism
Cardiovascular Physiological Phenomena
Exercise - physiology
Fatty Acids - blood
Female
Glucose - metabolism
Hormones - blood
Humans
Kinetics
Leg
Male
Muscle, Skeletal - metabolism
Physical Education and Training
Physical Endurance
Respiratory Physiological Phenomena
Sex Characteristics
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Summary:Departments of 1  Human Physiology and 2  Medical Physiology, Copenhagen Muscle Research Centre, University of Copenhagen; and 3  Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, DK-2100 Copenhagen, Denmark Substrate utilization across the leg during 90 min of bicycle exercise at 58% of peak oxygen uptake ( O 2 peak ) was studied in seven endurance-trained males and seven endurance-trained, eumenorrheic females by applying arteriovenous catheterization, stable isotopes, and muscle biopsies. The female and male groups were matched according to O 2 peak per kilogram of lean body mass, physical activity level, and training history of the subjects. All subjects consumed the same diet, well controlled in terms of nutrient composition as well as energy content, for 8 days preceding the experiment, and all females were tested in the midfollicular phase of the menstrual cycle. During exercise, respiratory exchange ratio (RER) and leg respiratory quotient (RQ) were similar in females and males. Myocellular triacylglycerol (TG) degradation was negligible in males but amounted to 12.4   ± 3.2 mmol/kg dry wt in females and corresponded to 25.0 ± 6.0   and 5.0 ± 7.3% of total oxygen uptake in females and males, respectively ( P  
ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.00266.2001