Bradykinin BK2 receptors contribute to reflex cardiovascular responses during brief abdominal ischemia

• Published in: American journal of physiology. Heart and circulatory physiology 1998-01, Vol.274 (1), p.H308
• Main Authors: Chahal, Premjit S, Rendig, Stephen V, Longhurst, John C
• Format: Article
• Language: English
• ISSN: 0363-6135; 1522-1539
• DOI: 10.1152/ajpheart.1998.274.1.h308

Division of Cardiovascular Medicine, Department of Internal Medicine, and Department of Human Physiology, University of California, Davis, California 95616 Ischemically sensitive visceral sympathetic nerve fibers, which are thought to represent the afferent limb of a strong cardiovascular pressor reflex, can be stimulated by exogenously applied bradykinin (BK). During ischemia, BK also is known to be produced locally and to serve as an endogenous stimulus for activation of ischemically sensitive nerve endings. It is unclear, however, whether ischemically induced BK production is sufficient to elicit a reflex cardiovascular response. Accordingly, femoral arterial and venous catheters were positioned in anesthetized cats, and the superior mesenteric and celiac arteries were isolated for placement of snare occluders. After dual occlusion of these arteries (20 min), one of two chemically dissimilar specific kinin B 2 (BK 2 ) receptor antagonists, HOE-140 (30-40 µg/kg iv, n  = 8) or NPC-17731 (30-40 µg/kg iv, n  = 11), was administered and dual occlusion was repeated. The reflex rise of mean arterial blood pressure (BP) of 16 ± 3.7% was significantly ( P