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Effects of autonomic disruption and inactivity on venous vascular function

1  Veterans Affairs Medical Center, Spinal Cord Damage Research Center and Medical Services, Bronx 10468; 2  Departments of Medicine and 3  Rehabilitation Medicine, Mount Sinai School of Medicine, New York 10029; 4  Department of Rehabilitation Medicine, College of Physicians and Surgeons, Columbia...

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Published in:American journal of physiology. Heart and circulatory physiology 2000-02, Vol.278 (2), p.H515-H520
Main Authors: Wecht, Jill M, de Meersman, Ronald E, Weir, Joseph P, Bauman, William A, Grimm, David R
Format: Article
Language:English
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Summary:1  Veterans Affairs Medical Center, Spinal Cord Damage Research Center and Medical Services, Bronx 10468; 2  Departments of Medicine and 3  Rehabilitation Medicine, Mount Sinai School of Medicine, New York 10029; 4  Department of Rehabilitation Medicine, College of Physicians and Surgeons, Columbia University, New York 10032; and 5  University of Osteopathic Medicine and Health Sciences, Des Moines, Iowa 50312 The effects of autonomic disruption and inactivity were studied on the venous vascular system. Forty-eight subjects, 24 with spinal cord injury (SCI) and 12 sedentary and 12 active able-bodied controls, participated in this study. Peripheral autonomic data were obtained to estimate sympathetic vasomotor control [low-frequency component of systolic blood pressure (LF SBP )]. Vascular parameters were determined using strain-gauge venous occlusion plethysmography: venous capacitance (VC), venous emptying rate (VER), and total venous outflow (VO t ). An additional vascular parameter was calculated: venous compliance [(VC/occlusion pressure) × 100]. VC and VO t were significantly different (SCI 
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.2000.278.2.h515