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Effects of autonomic disruption and inactivity on venous vascular function
1 Veterans Affairs Medical Center, Spinal Cord Damage Research Center and Medical Services, Bronx 10468; 2 Departments of Medicine and 3 Rehabilitation Medicine, Mount Sinai School of Medicine, New York 10029; 4 Department of Rehabilitation Medicine, College of Physicians and Surgeons, Columbia...
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| Published in: | American journal of physiology. Heart and circulatory physiology 2000-02, Vol.278 (2), p.H515-H520 |
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| container_end_page | H520 |
| container_issue | 2 |
| container_start_page | H515 |
| container_title | American journal of physiology. Heart and circulatory physiology |
| container_volume | 278 |
| creator | Wecht, Jill M de Meersman, Ronald E Weir, Joseph P Bauman, William A Grimm, David R |
| description | 1 Veterans Affairs Medical Center, Spinal Cord
Damage Research Center and Medical Services, Bronx 10468;
2 Departments of Medicine and
3 Rehabilitation Medicine, Mount Sinai School of
Medicine, New York 10029; 4 Department of
Rehabilitation Medicine, College of Physicians and Surgeons,
Columbia University, New York 10032; and
5 University of Osteopathic Medicine and Health
Sciences, Des Moines, Iowa 50312
The effects of autonomic disruption and inactivity
were studied on the venous vascular system. Forty-eight subjects, 24 with spinal cord injury (SCI) and 12 sedentary and 12 active
able-bodied controls, participated in this study. Peripheral autonomic
data were obtained to estimate sympathetic vasomotor control
[low-frequency component of systolic blood pressure
(LF SBP )]. Vascular parameters were determined
using strain-gauge venous occlusion plethysmography: venous
capacitance (VC), venous emptying rate (VER), and total venous outflow
(VO t ). An additional vascular parameter was calculated: venous compliance [(VC/occlusion pressure) × 100]. VC and VO t were significantly
different (SCI |
| doi_str_mv | 10.1152/ajpheart.2000.278.2.h515 |
| format | article |
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Damage Research Center and Medical Services, Bronx 10468;
2 Departments of Medicine and
3 Rehabilitation Medicine, Mount Sinai School of
Medicine, New York 10029; 4 Department of
Rehabilitation Medicine, College of Physicians and Surgeons,
Columbia University, New York 10032; and
5 University of Osteopathic Medicine and Health
Sciences, Des Moines, Iowa 50312
The effects of autonomic disruption and inactivity
were studied on the venous vascular system. Forty-eight subjects, 24 with spinal cord injury (SCI) and 12 sedentary and 12 active
able-bodied controls, participated in this study. Peripheral autonomic
data were obtained to estimate sympathetic vasomotor control
[low-frequency component of systolic blood pressure
(LF SBP )]. Vascular parameters were determined
using strain-gauge venous occlusion plethysmography: venous
capacitance (VC), venous emptying rate (VER), and total venous outflow
(VO t ). An additional vascular parameter was calculated: venous compliance [(VC/occlusion pressure) × 100]. VC and VO t were significantly
different (SCI < sedentary < active). VER adjusted for VC was not
different for any group comparison, whereas venous compliance was
significantly lower in the SCI group than in the able-bodied groups and
in the sedentary group compared with the active group. Regression
analysis for the total group revealed a significant relationship
between LF SBP and venous compliance ( r = 0.64, P < 0.0001). After controlling for LF SBP through
analysis of covariance, we found that mean differences for all venous
vascular parameters did not change from unadjusted mean values. Our
findings suggest that in subjects with SCI, the loss of sympathetic
vasomotor tone contributes more than inactivity to reductions in venous vascular function. Heightened VC, VO t , vasomotor tone, and
venous compliance in the active group compared with the sedentary group imply that regular endurance training contributes to optimal venous vascular function and peripheral autonomic integrity.
spinal cord injury; vasomotor tone; venous occlusion
plethysmography; autonomic nervous system</description><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 1522-1539</identifier><identifier>DOI: 10.1152/ajpheart.2000.278.2.h515</identifier><identifier>PMID: 10666083</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Autonomic Nervous System Diseases - physiopathology ; Compliance ; Female ; Humans ; Male ; Middle Aged ; Paraplegia - physiopathology ; Physical Fitness ; Quadriplegia - physiopathology ; Reference Values ; Sympathetic Nervous System - physiopathology ; Vasomotor System - physiopathology ; Veins - physiopathology</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 2000-02, Vol.278 (2), p.H515-H520</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-97c85dd739b2c8260e21dfcc25b7082753d0a148d7724ccb2ca6ea1e66fc46b43</citedby><cites>FETCH-LOGICAL-c522t-97c85dd739b2c8260e21dfcc25b7082753d0a148d7724ccb2ca6ea1e66fc46b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10666083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wecht, Jill M</creatorcontrib><creatorcontrib>de Meersman, Ronald E</creatorcontrib><creatorcontrib>Weir, Joseph P</creatorcontrib><creatorcontrib>Bauman, William A</creatorcontrib><creatorcontrib>Grimm, David R</creatorcontrib><title>Effects of autonomic disruption and inactivity on venous vascular function</title><title>American journal of physiology. Heart and circulatory physiology</title><addtitle>Am J Physiol Heart Circ Physiol</addtitle><description>1 Veterans Affairs Medical Center, Spinal Cord
Damage Research Center and Medical Services, Bronx 10468;
2 Departments of Medicine and
3 Rehabilitation Medicine, Mount Sinai School of
Medicine, New York 10029; 4 Department of
Rehabilitation Medicine, College of Physicians and Surgeons,
Columbia University, New York 10032; and
5 University of Osteopathic Medicine and Health
Sciences, Des Moines, Iowa 50312
The effects of autonomic disruption and inactivity
were studied on the venous vascular system. Forty-eight subjects, 24 with spinal cord injury (SCI) and 12 sedentary and 12 active
able-bodied controls, participated in this study. Peripheral autonomic
data were obtained to estimate sympathetic vasomotor control
[low-frequency component of systolic blood pressure
(LF SBP )]. Vascular parameters were determined
using strain-gauge venous occlusion plethysmography: venous
capacitance (VC), venous emptying rate (VER), and total venous outflow
(VO t ). An additional vascular parameter was calculated: venous compliance [(VC/occlusion pressure) × 100]. VC and VO t were significantly
different (SCI < sedentary < active). VER adjusted for VC was not
different for any group comparison, whereas venous compliance was
significantly lower in the SCI group than in the able-bodied groups and
in the sedentary group compared with the active group. Regression
analysis for the total group revealed a significant relationship
between LF SBP and venous compliance ( r = 0.64, P < 0.0001). After controlling for LF SBP through
analysis of covariance, we found that mean differences for all venous
vascular parameters did not change from unadjusted mean values. Our
findings suggest that in subjects with SCI, the loss of sympathetic
vasomotor tone contributes more than inactivity to reductions in venous vascular function. Heightened VC, VO t , vasomotor tone, and
venous compliance in the active group compared with the sedentary group imply that regular endurance training contributes to optimal venous vascular function and peripheral autonomic integrity.
spinal cord injury; vasomotor tone; venous occlusion
plethysmography; autonomic nervous system</description><subject>Adult</subject><subject>Autonomic Nervous System Diseases - physiopathology</subject><subject>Compliance</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Paraplegia - physiopathology</subject><subject>Physical Fitness</subject><subject>Quadriplegia - physiopathology</subject><subject>Reference Values</subject><subject>Sympathetic Nervous System - physiopathology</subject><subject>Vasomotor System - physiopathology</subject><subject>Veins - physiopathology</subject><issn>0363-6135</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNp1kMtOAyEARYnRaH38gmHlbkYeBabujPEZEze6JpSHg5kOIzDV_r00VevGFQmce7k5AECMaowZOVdvQ2tVzDVBCNVENDWpW4bZDpiUZ1JhRme7YIIopxXHlB2Aw5TeCssEp_vgACPOOWroBDxcO2d1TjA4qMYc-rDwGhqf4jhkH3qoegN9r3T2S59XsNwsbR_GBJcq6bFTEbqx12v0GOw51SV78n0egZeb6-eru-rx6fb-6vKx0mVarmZCN8wYQWdzohvCkSXYOK0JmwvUEMGoQQpPGyMEmWpdIMWtwpZzp6d8PqVH4GzTO8TwPtqU5cInbbtO9bYMkwLNkGi4KGCzAXUMKUXr5BD9QsWVxEiuPcofj3LtURaPksi74rFET7__GOcLa_4EN-IKcLEBWv_afvho5dCukg9deF3Jm7Hrnu1n_u3fNsvBuBKu_w9vN23nfAGhopit</recordid><startdate>20000201</startdate><enddate>20000201</enddate><creator>Wecht, Jill M</creator><creator>de Meersman, Ronald E</creator><creator>Weir, Joseph P</creator><creator>Bauman, William A</creator><creator>Grimm, David R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000201</creationdate><title>Effects of autonomic disruption and inactivity on venous vascular function</title><author>Wecht, Jill M ; de Meersman, Ronald E ; Weir, Joseph P ; Bauman, William A ; Grimm, David R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-97c85dd739b2c8260e21dfcc25b7082753d0a148d7724ccb2ca6ea1e66fc46b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Autonomic Nervous System Diseases - physiopathology</topic><topic>Compliance</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Paraplegia - physiopathology</topic><topic>Physical Fitness</topic><topic>Quadriplegia - physiopathology</topic><topic>Reference Values</topic><topic>Sympathetic Nervous System - physiopathology</topic><topic>Vasomotor System - physiopathology</topic><topic>Veins - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wecht, Jill M</creatorcontrib><creatorcontrib>de Meersman, Ronald E</creatorcontrib><creatorcontrib>Weir, Joseph P</creatorcontrib><creatorcontrib>Bauman, William A</creatorcontrib><creatorcontrib>Grimm, David R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wecht, Jill M</au><au>de Meersman, Ronald E</au><au>Weir, Joseph P</au><au>Bauman, William A</au><au>Grimm, David R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of autonomic disruption and inactivity on venous vascular function</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol Heart Circ Physiol</addtitle><date>2000-02-01</date><risdate>2000</risdate><volume>278</volume><issue>2</issue><spage>H515</spage><epage>H520</epage><pages>H515-H520</pages><issn>0363-6135</issn><eissn>1522-1539</eissn><abstract>1 Veterans Affairs Medical Center, Spinal Cord
Damage Research Center and Medical Services, Bronx 10468;
2 Departments of Medicine and
3 Rehabilitation Medicine, Mount Sinai School of
Medicine, New York 10029; 4 Department of
Rehabilitation Medicine, College of Physicians and Surgeons,
Columbia University, New York 10032; and
5 University of Osteopathic Medicine and Health
Sciences, Des Moines, Iowa 50312
The effects of autonomic disruption and inactivity
were studied on the venous vascular system. Forty-eight subjects, 24 with spinal cord injury (SCI) and 12 sedentary and 12 active
able-bodied controls, participated in this study. Peripheral autonomic
data were obtained to estimate sympathetic vasomotor control
[low-frequency component of systolic blood pressure
(LF SBP )]. Vascular parameters were determined
using strain-gauge venous occlusion plethysmography: venous
capacitance (VC), venous emptying rate (VER), and total venous outflow
(VO t ). An additional vascular parameter was calculated: venous compliance [(VC/occlusion pressure) × 100]. VC and VO t were significantly
different (SCI < sedentary < active). VER adjusted for VC was not
different for any group comparison, whereas venous compliance was
significantly lower in the SCI group than in the able-bodied groups and
in the sedentary group compared with the active group. Regression
analysis for the total group revealed a significant relationship
between LF SBP and venous compliance ( r = 0.64, P < 0.0001). After controlling for LF SBP through
analysis of covariance, we found that mean differences for all venous
vascular parameters did not change from unadjusted mean values. Our
findings suggest that in subjects with SCI, the loss of sympathetic
vasomotor tone contributes more than inactivity to reductions in venous vascular function. Heightened VC, VO t , vasomotor tone, and
venous compliance in the active group compared with the sedentary group imply that regular endurance training contributes to optimal venous vascular function and peripheral autonomic integrity.
spinal cord injury; vasomotor tone; venous occlusion
plethysmography; autonomic nervous system</abstract><cop>United States</cop><pmid>10666083</pmid><doi>10.1152/ajpheart.2000.278.2.h515</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-6135 |
| ispartof | American journal of physiology. Heart and circulatory physiology, 2000-02, Vol.278 (2), p.H515-H520 |
| issn | 0363-6135 1522-1539 |
| language | eng |
| recordid | cdi_highwire_physiology_ajpheart_278_2_H515 |
| source | American Physiological Society Free |
| subjects | Adult Autonomic Nervous System Diseases - physiopathology Compliance Female Humans Male Middle Aged Paraplegia - physiopathology Physical Fitness Quadriplegia - physiopathology Reference Values Sympathetic Nervous System - physiopathology Vasomotor System - physiopathology Veins - physiopathology |
| title | Effects of autonomic disruption and inactivity on venous vascular function |
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