Regional effect of naltrexone in the nucleus of the solitary tract in blockade of NPY-induced feeding

1  Departments of Food Science and Nutrition, 3  Psychiatry, and 4  Medicine, University of Minnesota, Saint Paul 55108; and 2  Minnesota Obesity Center, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417 Naltrexone (NLTX) in the nucleus of the solitary tract (NTS) decreases feeding induc...

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Bibliographic Details
Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2000-02, Vol.278 (2), p.499-R503
Main Authors: Kotz, C. M, Glass, M. J, Levine, A. S, Billington, C. J
Format: Article
Language:English
Subjects:
Animals
Dose-Response Relationship, Drug
Eating - drug effects
Eating - physiology
Injections
Male
Naltrexone - pharmacology
Narcotic Antagonists - pharmacology
Neuropeptide Y - pharmacology
Rats
Rats, Sprague-Dawley
Rhombencephalon - physiology
Solitary Nucleus - physiology
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Summary:1  Departments of Food Science and Nutrition, 3  Psychiatry, and 4  Medicine, University of Minnesota, Saint Paul 55108; and 2  Minnesota Obesity Center, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417 Naltrexone (NLTX) in the nucleus of the solitary tract (NTS) decreases feeding induced by neuropeptide Y (NPY) in the paraventricular nucleus (PVN). We sought to determine the NTS region most sensitive to NLTX blockade of PVN NPY-induced feeding. Male Sprague-Dawley rats were fitted with two cannulas; one in the PVN and one in a hindbrain region: caudal, medial, or rostral NTS or 1 mm outside the NTS. Animals received NLTX (0, 1, 3, 10, and 30 µg in 0.3   µl) into the hindbrain region just prior to PVN NPY (0.5 µg, 0.3   µl) or artificial cerebrospinal fluid (0.3 µl). Food intake was measured at 2 h following injection. PVN NPY stimulated feeding, and NLTX in the medial NTS significantly decreased NPY-induced feeding at 2 h, whereas administration of NLTX in the other hindbrain regions did not significantly influence PVN NPY induced feeding. These data suggest that opioid receptors in the medial NTS are most responsive to feeding signals originating in the PVN after NPY stimulation. feeding behavior; hypothalamic paraventricular nucleus; opioid receptor; brain mapping
ISSN:0363-6119
1522-1490
DOI:10.1152/ajpregu.2000.278.2.R499