Exercise exacerbates acute mountain sickness at simulated high altitude

1  Division of Physiology, Department of Life Sciences, New Mexico Highlands University, Las Vegas 87701-9000; 2  Lovelace Respiratory Research Institutes, Albuquerque 87108-5127; 3  Department of Health Promotion, Physical Activity, and Exercise, University of New Mexico, Albuquerque 87131-5686; 4...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 2000-02, Vol.88 (2), p.581-585
Main Authors: Roach, R. C, Maes, D, Sandoval, D, Robergs, R. A, Icenogle, M, Hinghofer-Szalkay, H, Lium, D, Loeppky, J. A
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Altitude
Altitude Sickness - physiopathology
Anatomy & physiology
Atmospheric Pressure
Biological and medical sciences
Drinking - physiology
Exercise
Exercise - physiology
Humans
Kidney - physiopathology
Kidney Function Tests
Male
Medical disorders
Medical sciences
Oxygen
Severity of Illness Index
Space life sciences
Transport. Aerospace. Diving. Altitude
Traumas. Diseases due to physical agents
Urination - physiology
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Summary:1  Division of Physiology, Department of Life Sciences, New Mexico Highlands University, Las Vegas 87701-9000; 2  Lovelace Respiratory Research Institutes, Albuquerque 87108-5127; 3  Department of Health Promotion, Physical Activity, and Exercise, University of New Mexico, Albuquerque 87131-5686; 4  VA Hospital and Department of Cardiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131-5686; and 5  Department of Physiology, School of Medicine, University of Graz, A-8010 Graz, Austria . We hypothesized that exercise would cause greater severity and incidence of acute mountain sickness (AMS) in the early hours of exposure to altitude. After passive ascent to simulated high altitude in a decompression chamber [barometric pressure = 429   Torr, ~4,800 m (J. B. West, J. Appl. Physiol. 81: 1850-1854, 1996)], seven men exercised (Ex) at 50% of their altitude-specific maximal workload four times for 30 min in the first 6 h of a 10-h exposure. On another day they completed the same protocol but were sedentary (Sed). Measurements included an AMS symptom score, resting minute ventilation ( E ), pulmonary function, arterial oxygen saturation (Sa O 2 ), fluid input, and urine volume. Symptoms of AMS were worse in Ex than Sed, with peak AMS scores of 4.4 ± 1.0 and 1.3 ± 0.4   in Ex and Sed, respectively ( P  
ISSN:8750-7587
1522-1601
DOI:10.1152/jappl.2000.88.2.581