Preservation of neural function in the perinate by high PGE2 levels acting via EP2 receptors

1  Department of Pharmacology and Therapeutics and 2  Department of Ophthalmology and Laboratory of Visual Electrophysiology, McGill University, Montreal, Quebec H3G 1Y6; and 3  Departments of Pediatrics, Ophthalmology, and Pharmacology, Research Center of Hôpital Ste.-Justine, Montreal, Quebec, Can...

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Published in:Journal of applied physiology (1985) 2000-08, Vol.89 (2), p.777-784
Main Authors: Najarian, Taline, Hardy, Pierre, Hou, Xin, Lachapelle, Julie, Doke, Anjali, Gobeil, Fernand, Jr, Roy, Marie-Sylvie, Lachapelle, Pierre, Varma, Daya R, Chemtob, Sylvain
Format: Article
Language:English
Subjects:
Amino acids
Babies
Biological and medical sciences
Births
Fundamental and applied biological sciences. Psychology
Neurology
Prostaglandins. Arachidonic acid metabolites
Vertebrates: endocrinology
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Summary:1  Department of Pharmacology and Therapeutics and 2  Department of Ophthalmology and Laboratory of Visual Electrophysiology, McGill University, Montreal, Quebec H3G 1Y6; and 3  Departments of Pediatrics, Ophthalmology, and Pharmacology, Research Center of Hôpital Ste.-Justine, Montreal, Quebec, Canada H3T 1C5 Despite increasingly frequent and longer lasting hypoxic episodes during progressive labor, the neonate is alert and vigorous at birth. We investigated whether high levels of PGs during the perinatal period assist in preserving neural function after such "stressful" hypoxic events. Visual evoked potentials (VEPs) and electroretinograms (ERGs) were recorded before and 45 min after mild moderate asphyxic hypoxia (two 4-min asphyxic-hypoxic periods induced by interrupting ventilation at 8-min intervals) in newborn piglets
ISSN:8750-7587
1522-1601
DOI:10.1152/jappl.2000.89.2.777