Time and Frequency Characteristics of Purkinje Cell Complex Spikes in the Awake Monkey Performing a Nonperiodic Task

Department of Anatomy and Neurobiology. Washington University School of Medicine, St. Louis, Missouri Submitted 13 February 2008; accepted in final form 18 May 2008 A number of studies have been interpreted to support the view that the inferior olive climbing fibers send periodic signals to the cere...

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Published in:Journal of neurophysiology 2008-08, Vol.100 (2), p.1032-1040
Main Authors: Hakimian, Shahin, Norris, Scott A, Greger, Bradley, Keating, Jeffrey G, Anderson, Charles H, Thach, W. Thomas
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Animals
Behavior, Animal
Cell Count - methods
Cerebellum - cytology
Fourier Analysis
Functional Laterality
Macaca mulatta
Nerve Fibers - physiology
Psychomotor Performance - physiology
Purkinje Cells - physiology
Statistics as Topic
Task Performance and Analysis
Time Factors
Wakefulness
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Summary:Department of Anatomy and Neurobiology. Washington University School of Medicine, St. Louis, Missouri Submitted 13 February 2008; accepted in final form 18 May 2008 A number of studies have been interpreted to support the view that the inferior olive climbing fibers send periodic signals to the cerebellum to time and pace behavior. In a direct test of this hypothesis in macaques performing nonperiodic tasks, we analyzed continuous recordings of complex spikes from the lateral cerebellar hemisphere. We found no periodicity outside of a 100-ms relative refractory period. Address for reprint requests and other correspondence: W. T. Thach, Dept. of Anatomy and Neurobiology, Washington University School of Medicine, Box 8108, 660 S. Euclid Ave., St. Louis, MO 63110 (E-mail: thachw{at}pcg.wustl.edu )
ISSN:0022-3077
1522-1598
DOI:10.1152/jn.90277.2008