The Role of Apoptosis in the Ameliorating Effects of a CDR1-Based Peptide on Lupus Manifestations in a Mouse Model

Experimental systemic lupus erythematosus (SLE) can be induced in mice following immunization with an anti-DNA mAb expressing a major Id, 16/6Id. Treatment with a peptide, designated human CDR1 (hCDR1; Edratide), that is based on the sequence of CDR1 of the 16/6Id ameliorated disease manifestations....

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Bibliographic Details
Published in:Journal of Immunology 2007-10, Vol.179 (8), p.4979-4987
Main Authors: Sharabi, Amir, Luger, Dror, Ben-David, Hava, Dayan, Molly, Zinger, Heidey, Mozes, Edna
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Apoptosis - immunology
Apoptosis Regulatory Proteins - physiology
bcl-X Protein - biosynthesis
Caspase 3 - biosynthesis
Caspase 8 - biosynthesis
Caspase Inhibitors
Disease Models, Animal
Down-Regulation - immunology
Female
Humans
Lupus Erythematosus, Systemic - enzymology
Lupus Erythematosus, Systemic - metabolism
Lupus Erythematosus, Systemic - pathology
Lupus Erythematosus, Systemic - prevention & control
Mice
Mice, Inbred BALB C
Molecular Sequence Data
Nerve Tissue Proteins - physiology
Peptides - physiology
Up-Regulation - immunology
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