The Identification of Subsequent Events Following Out-of-Hospital Cardiac Arrests with Targeted Temperature Management

Background: Out-of-hospital cardiac arrest (OHCA) is a critical issue due to poor neurological outcomes and high mortality rate. Severe ischemia and reperfusion injury often occur after cardiopulmonary resuscitation (CPR) and return of spontaneous circulation (ROSC). Targeted temperature management...

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Bibliographic Details
Published in:Acta Cardiologica Sinica 2023-11, Vol.39 (6), p.831-840
Main Authors: Chia-Chen Lee, Hsiao-Yun Cheuh, Sheng-Nan Chang
Format: Article
Language:Chinese
Subjects:
Cardiopulmonary resuscitation
MEDLINE
Out-of-hospital cardiac arrest
Return of spontaneous circulation
SCIE
Scopus
Targeted temperature management
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Summary:Background: Out-of-hospital cardiac arrest (OHCA) is a critical issue due to poor neurological outcomes and high mortality rate. Severe ischemia and reperfusion injury often occur after cardiopulmonary resuscitation (CPR) and return of spontaneous circulation (ROSC). Targeted temperature management (TTM) has been shown to reduce neurological complications among OHCA survivors. However, it is unclear how "time-to-cool" influences clinical outcomes. In this study, we investigated the optimal timing to reach target temperature after cardiac arrest and ROSC. ＜br＞ Methods: A total of 568 adults with OHCA and ROSC were admitted for targeted hypothermia assessment. Several events were predicted, including pneumonia, septic shock, gastrointestinal (GI) bleeding, and death. ＜br＞ Results: One hundred and eighteen patients [70 men (59.32%); 48 women (40.68%)] were analyzed for clinical outcomes. The duration of CPR after ROSC was significantly associated with pneumonia, septic shock, GI bleeding, and mortality after TTM
ISSN:1011-6842