Noninvasive Assessment of Cardiovascular Autonomic Control in Congenital Central Hypoventilation Syndrome

The goal of this study was to quantify autonomic system dysfunction, as manifested by cardiovascular and respiratory response abnormalities, in patients with congenital central hypoventilation syndrome (CCHS). During wakefulness, we continuously measured the ECG, arterial blood pressure (ABP), airfl...

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Bibliographic Details
Main Authors: Lin, Z., Chen, M.L., Keens, T.G., Ward, S.L.D., Khoo, M.C.K.
Format: Conference Proceeding
Language:English
Subjects:
Arterial blood pressure
Baroreflex
Cardiology
cardiovascular control
Centralized control
Electrocardiography
heart rate variability
hypercapnia
hypoxia
minimal closed-loop model
Performance evaluation
Positron emission tomography
Pressure measurement
respiratory sinus arrhythmia
Spectral analysis
Stress control
Testing
ventilatory control
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Summary:The goal of this study was to quantify autonomic system dysfunction, as manifested by cardiovascular and respiratory response abnormalities, in patients with congenital central hypoventilation syndrome (CCHS). During wakefulness, we continuously measured the ECG, arterial blood pressure (ABP), airflow, end-tidal CO 2 partial pressure (PET CO2 ), and arterial oxygen saturation (SatO 2 ) in each subject. These measurements were made during spontaneous breathing in supine, sitting and standing postures, and also when each subject tracked his/her prior spontaneous breathing pattern while supine. We also performed the cold face test, hyperoxic hypercapnic rebreathing and the isocapnic hypoxic rebreathing challenges. Using spectral analysis and modeling techniques, we sought to computationally delineate the physiological mechanisms that mediate these abnormalities, as well as to determine the extent to which these abnormalities are related to peripheral or central chemoreflex dysfunction. Our preliminary results support the notion that sympathetic tone is markedly elevated in CCHS, and that differences in autonomic control from normal controls can be delineated by observing the responses to different stressors.
DOI:10.1109/IEMBS.2004.1404083