Modifying the Hodgkin-Huxley Model for High Frequency AC Stimulation

Prior studies have shown that a reversible nerve conduction block can be induced by applying a high frequency alternating current (HFAC) electrical stimulus at frequencies above approximately 3kHz. The potential clinical and electrophysiological applications of this technique have led to a series of...

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Bibliographic Details
Main Authors: Haeffele, B.D., Butera, R.J.
Format: Conference Proceeding
Language:English
Subjects:
Animals
Biomedical engineering
Biomembranes
Capacitance
Electrical stimulation
Frequency
Nerve fibers
Neural engineering
Predictive models
Voltage
Online Access:Request full text
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Summary:Prior studies have shown that a reversible nerve conduction block can be induced by applying a high frequency alternating current (HFAC) electrical stimulus at frequencies above approximately 3kHz. The potential clinical and electrophysiological applications of this technique have led to a series of modeling studies analyzing the physiological mechanism that generates a HFAC conduction block; however, many of these studies have been based on axon models that are perhaps not valid for HFAC electrical stimulation. We show that the Hodgkin-Huxley model does not accurately predict trends observed in HFAC conduction block experiments on unmyelinated nerve fibers over a frequency range from 3kHz to 50kHz. Further, modifying the Hodgkin-Huxley model to incorporate a frequency-dependent membrane capacitance results in a significant change in the high frequency response of the model while still preserving the standard characteristics of action potential propagation
ISSN:1948-3546
1948-3554
DOI:10.1109/CNE.2007.369731