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Modifying the Hodgkin-Huxley Model for High Frequency AC Stimulation
Prior studies have shown that a reversible nerve conduction block can be induced by applying a high frequency alternating current (HFAC) electrical stimulus at frequencies above approximately 3kHz. The potential clinical and electrophysiological applications of this technique have led to a series of...
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| creator | Haeffele, B.D. Butera, R.J. |
| description | Prior studies have shown that a reversible nerve conduction block can be induced by applying a high frequency alternating current (HFAC) electrical stimulus at frequencies above approximately 3kHz. The potential clinical and electrophysiological applications of this technique have led to a series of modeling studies analyzing the physiological mechanism that generates a HFAC conduction block; however, many of these studies have been based on axon models that are perhaps not valid for HFAC electrical stimulation. We show that the Hodgkin-Huxley model does not accurately predict trends observed in HFAC conduction block experiments on unmyelinated nerve fibers over a frequency range from 3kHz to 50kHz. Further, modifying the Hodgkin-Huxley model to incorporate a frequency-dependent membrane capacitance results in a significant change in the high frequency response of the model while still preserving the standard characteristics of action potential propagation |
| doi_str_mv | 10.1109/CNE.2007.369731 |
| format | conference_proceeding |
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Further, modifying the Hodgkin-Huxley model to incorporate a frequency-dependent membrane capacitance results in a significant change in the high frequency response of the model while still preserving the standard characteristics of action potential propagation</description><subject>Animals</subject><subject>Biomedical engineering</subject><subject>Biomembranes</subject><subject>Capacitance</subject><subject>Electrical stimulation</subject><subject>Frequency</subject><subject>Nerve fibers</subject><subject>Neural engineering</subject><subject>Predictive models</subject><subject>Voltage</subject><issn>1948-3546</issn><issn>1948-3554</issn><isbn>9781424407910</isbn><isbn>1424407915</isbn><isbn>1424407923</isbn><isbn>9781424407927</isbn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2007</creationdate><recordtype>conference_proceeding</recordtype><sourceid>6IE</sourceid><recordid>eNo9zMlOwzAUhWEzSZSSNQs2foGE6yGxvaxCS5AKLIB15cbXqSFNIINE3p5KDNKR_sUnHUKuGCSMgbnJH5cJB1CJyIwS7IhcMMmlBGW4OCYzZqSORZrKExIZpf-Mwem_yeycRH3_BgCCg2RGz8jtQ-uCn0JT0WGHtGhd9R6auBi_apzoAbGmvu1oEaodXXX4OWJTTnSR0-ch7MfaDqFtLsmZt3WP0W_n5HW1fMmLeP10d58v1nFgKh3i7dYqmyKA9EpLppm3xoP3rlSlLn1m8TBAq9GmHFzqMHNCS2EYOqetF3Ny_fMbEHHz0YW97aaN5FwJkYlvzmRQDA</recordid><startdate>200705</startdate><enddate>200705</enddate><creator>Haeffele, B.D.</creator><creator>Butera, R.J.</creator><general>IEEE</general><scope>6IE</scope><scope>6IL</scope><scope>CBEJK</scope><scope>RIE</scope><scope>RIL</scope></search><sort><creationdate>200705</creationdate><title>Modifying the Hodgkin-Huxley Model for High Frequency AC Stimulation</title><author>Haeffele, B.D. ; Butera, R.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i175t-bba7a5e004f784181fa9f0ffdc7c8cf6ae6ae0ea8ea520d5de6d384391edd8af3</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Biomedical engineering</topic><topic>Biomembranes</topic><topic>Capacitance</topic><topic>Electrical stimulation</topic><topic>Frequency</topic><topic>Nerve fibers</topic><topic>Neural engineering</topic><topic>Predictive models</topic><topic>Voltage</topic><toplevel>online_resources</toplevel><creatorcontrib>Haeffele, B.D.</creatorcontrib><creatorcontrib>Butera, R.J.</creatorcontrib><collection>IEEE Electronic Library (IEL) Conference Proceedings</collection><collection>IEEE Proceedings Order Plan All Online (POP All Online) 1998-present by volume</collection><collection>IEEE Xplore All Conference Proceedings</collection><collection>IEEE Electronic Library (IEL)</collection><collection>IEEE Proceedings Order Plans (POP All) 1998-Present</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Haeffele, B.D.</au><au>Butera, R.J.</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Modifying the Hodgkin-Huxley Model for High Frequency AC Stimulation</atitle><btitle>2007 3rd International IEEE/EMBS Conference on Neural Engineering</btitle><stitle>CNE</stitle><date>2007-05</date><risdate>2007</risdate><spage>550</spage><epage>552</epage><pages>550-552</pages><issn>1948-3546</issn><eissn>1948-3554</eissn><isbn>9781424407910</isbn><isbn>1424407915</isbn><eisbn>1424407923</eisbn><eisbn>9781424407927</eisbn><abstract>Prior studies have shown that a reversible nerve conduction block can be induced by applying a high frequency alternating current (HFAC) electrical stimulus at frequencies above approximately 3kHz. The potential clinical and electrophysiological applications of this technique have led to a series of modeling studies analyzing the physiological mechanism that generates a HFAC conduction block; however, many of these studies have been based on axon models that are perhaps not valid for HFAC electrical stimulation. We show that the Hodgkin-Huxley model does not accurately predict trends observed in HFAC conduction block experiments on unmyelinated nerve fibers over a frequency range from 3kHz to 50kHz. Further, modifying the Hodgkin-Huxley model to incorporate a frequency-dependent membrane capacitance results in a significant change in the high frequency response of the model while still preserving the standard characteristics of action potential propagation</abstract><pub>IEEE</pub><doi>10.1109/CNE.2007.369731</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 1948-3546 |
| ispartof | 2007 3rd International IEEE/EMBS Conference on Neural Engineering, 2007, p.550-552 |
| issn | 1948-3546 1948-3554 |
| language | eng |
| recordid | cdi_ieee_primary_4227336 |
| source | IEEE Xplore All Conference Series |
| subjects | Animals Biomedical engineering Biomembranes Capacitance Electrical stimulation Frequency Nerve fibers Neural engineering Predictive models Voltage |
| title | Modifying the Hodgkin-Huxley Model for High Frequency AC Stimulation |
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