Hemi-Parkinsonian Rat Motor/Non-Motor Symptom Evaluation with Deep Brain Stimulation

arkinson's Disease can be modelled in rats to investigate the impact of dopamine loss. Unilateral lesions, using 6-OHDA, cause a degeneration of the dopaminergic neurons of the nigrostriatal pathway resulting in motor deficits. The experiments performed in this study aimed to compare the motor...

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Bibliographic Details
Main Authors: Mottaghi, S., Kohl, S., Liebana, S., Wilson, M., Klaus, C., Munkel, C., Hofmann, U.G.
Format: Conference Proceeding
Language:English
Subjects:
Brain stimulation
Parkinson's disease
Rats
Satellite broadcasting
Sleep
Training
Online Access:Request full text
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Summary:arkinson's Disease can be modelled in rats to investigate the impact of dopamine loss. Unilateral lesions, using 6-OHDA, cause a degeneration of the dopaminergic neurons of the nigrostriatal pathway resulting in motor deficits. The experiments performed in this study aimed to compare the motor and non-motor behaviour of healthy rats vs. lesioned rats (PD). We also assessed the effect that deep brain stimulation (DBS) has on the animals' locomotor activity. This paper covers the rotarod, open field, and cylinder tests, as well as sleep-awake analysis. The results of the rotarod test show that healthy rats are able to stay on the rod for longer than PD rats. The open field test revealed that PD rats spend more time freezing and close to walls or corners, whereas healthy and stimulated rats are more motivated to explore. In the cylinder test, during DBS, there is an increase in both right and left paw touches on the cylinder wall compared to pre- and post-DBS. It has also been shown that PD and control rats show different sleep patterns, further experiments could be helpful to better understand this difference.
ISSN:1948-3554
DOI:10.1109/NER.2019.8717047