Investigation of the analysis of wearable data for cancer-specific mortality prediction in older adults

• Main Authors: Tedesco, Salvatore, Andrulli, Martina, Larsson, Markus Akerlund, Kelly, Daniel, Timmons, Suzanne, Alamaki, Antti, Barton, John, Condell, Joan, O'Flynn, Brendan, Nordstrom, Anna
• Format: Conference Proceeding
• Language: English
• Subjects: Aged; Analytical models; Biological system modeling; Biomarkers; Cancer; Data models; Electronic Health Records; Humans; Longitudinal Studies; Mortality; Neoplasms - diagnosis; Older Adults; Prediction; Self Report; Soft sensors; Wearable Electronic Devices; Wearables
• ISSN: 2694-0604
• DOI: 10.1109/EMBC46164.2021.9630370

Cancer is an aggressive disease which imparts a tremendous socio-economic burden on the international community. Early detection is an important aspect in improving survival rates for cancer sufferers; however, very few studies have investigated the possibility of predicting which people have the highest risk to develop this disease, even years before the traditional symptoms first occur. In this paper, a dataset from a longitudinal study which was collected among 2291 70-year olds in Sweden has been analyzed to investigate the possibility for predicting 2-7 year cancer-specific mortality. A tailored ensemble model has been developed to tackle this highly imbalanced dataset. The performance with different feature subsets has been investigated to evaluate the impact that heterogeneous data sources may have on the overall model. While a full-features model shows an Area Under the ROC Curve (AUC-ROC) of 0.882, a feature subset which only includes demographics, self-report health and lifestyle data, and wearable dataset collected in free-living environments presents similar performance (AUC-ROC: 0.857). This analysis confirms the importance of wearable technology for providing unbiased health markers and suggests its possible use in the accurate prediction of 2-7 year cancer-related mortality in older adults.