Duodenal infusion of different nutrients and the site of gaseous stimulation influence intestinal gas dynamics

Objective. Excessive intestinal gas can be involved in postprandial abdominal symptom generation, but whether the small bowel influences intestinal gas dynamics, depending on the ingested meal, remains to be demonstrated. We compare the intestinal response to a proximal and distal small intestinal g...

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Published in:Scandinavian journal of gastroenterology 2006-03, Vol.41 (3), p.294-301
Main Authors: Harder, Hermann, Hernando-Harder, Ana C., Franke, Andreas, Erguel, Guelsah S., Krammer, Heinz-Juergen, Singer, Manfred V.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Bloating
Duodenum
Enteral Nutrition - methods
Female
Flatulence - metabolism
Flatulence - physiopathology
Gases - pharmacology
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal Transit - drug effects
Humans
Ileum - drug effects
Ileum - physiopathology
intestinal gas
Jejunum - drug effects
Jejunum - physiopathology
Male
Medical sciences
nutrients
perception
Perception - physiology
postprandial gas retention
Postprandial Period
visceral sensitivity
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Summary:Objective. Excessive intestinal gas can be involved in postprandial abdominal symptom generation, but whether the small bowel influences intestinal gas dynamics, depending on the ingested meal, remains to be demonstrated. We compare the intestinal response to a proximal and distal small intestinal gas challenge during different duodenal nutrient components. Material and methods. We randomly studied 32 healthy subjects, twice, on different days with a gas mixture infused at 12 ml/min either directly into the proximal jejunum or into the ileum; during duodenal lipids, amino acids, glucose, at 1 kcal/min each, or saline (n=8 for each group). Gas evacuation was monitored continuously and abdominal perception and girth changes were assessed. Results. In response to the jejunal gas challenge, duodenal lipids delayed intestinal gas clearance more potently than amino acids (733±26 ml and 541±108 ml final gas retention; p
ISSN:0036-5521
1502-7708
DOI:10.1080/00365520500217134