Formulation, Characterization, and In Vitro Release of Glyburide from Proliposomal Beads

The objective of our study was to formulate and evaluate proliposomes in the form of enteric-coated beads using glyburide as a model drug. The beads were enteric coated with Eudragit L-100 by a fluidized bed coating process using triethyl citrate as plasticizer. Content uniformity of glyburide was e...

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Bibliographic Details
Published in:Drug delivery 2001, Vol.8 (1), p.25-27
Main Author: Rajesh Kumar, Ram B. Gupta, Guru V. Betageri
Format: Article
Language:English
Subjects:
Beads Enteric Dissolution Glyburide Proliposomes
Chemistry, Pharmaceutical
Chromatography, High Pressure Liquid
Drug Delivery Systems
Glyburide - pharmacokinetics
Hypoglycemic Agents - pharmacokinetics
In Vitro Techniques
Liposomes
Microscopy, Electron
Microspheres
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Summary:The objective of our study was to formulate and evaluate proliposomes in the form of enteric-coated beads using glyburide as a model drug. The beads were enteric coated with Eudragit L-100 by a fluidized bed coating process using triethyl citrate as plasticizer. Content uniformity of glyburide was estimated using HPLC analysis of beads dissolved in methanol. These proliposomal beads formed liposomes on disintegration in phosphate buffered saline (pH 7.4), which was confirmed by transmission electron microscopy. The dissolution study of enteric-coated beads exhibited enhanced dissolution compared with pure drug and a marketed product. Liposomes can be successfully prepared for oral administration in the form of enteric-coated beads that may offer a stable system to produce liposomes for oral administration.
ISSN:0049-8254
1071-7544
1366-5928
1521-0464
DOI:10.1080/107175401300002720