GENDER DIFFERENCE IN THE RELATIONSHIPS AMONG HYPERLEPTINEMIA, HYPERINSULINEMIA, AND HYPERTENSION

Studies reveals that plasma leptin levels (LEP) in females are higher than those in males, and that LEP in hypertensive subjects are higher than those in BMI-matched normotensive subjects. To investigate the relationships among LEP, blood pressure (BP) and insulin sensitivity, we studied these relat...

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Bibliographic Details
Published in:Clinical and experimental hypertension (1993) 2001, Vol.23 (4), p.357-368
Main Authors: Takizawa, Hideki, Ura, Nobuyuki, Saitoh, Shigeyuki, Wang, Ling, Higashiura, Katsuhiro, Takagi, Satoru, Takada, Mikio, Togashi, Nobuhiko, Nakano, Masahiro, Hayashi, Yoshito, Shimamoto, Kazuaki
Format: Article
Language:English
Subjects:
Adult
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Body Mass Index
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Female
Gender difference
Humans
Hyperinsulinism - blood
Hyperinsulinism - complications
Hypertension
Hypertension - blood
Hypertension - complications
Insulin - blood
Insulin Resistance
Insulin-resistant hypertension
Japan
Leptin
Leptin - blood
Male
Medical sciences
Middle Aged
Population Surveillance
Sex Factors
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Summary:Studies reveals that plasma leptin levels (LEP) in females are higher than those in males, and that LEP in hypertensive subjects are higher than those in BMI-matched normotensive subjects. To investigate the relationships among LEP, blood pressure (BP) and insulin sensitivity, we studied these relationships in 133 Japanese males and 263 females. LEP were positively correlated with BP, body mass index, body fat mass (FM) and homeostasis model assessment (HOMA). Regression analysis in which age and FM were adjusted showed LEP were associated with BP and HOMA. Even with adjustment by age, FM and HOMA, LEP were still positively correlated BP in males. LEP in insulin-resistant hypertensives was significantly higher than those in insulin-sensitive hypertensives, in insulin-sensitive normotensives and in insulin-resistant normotensives in males. However, in females, a significantly higher LEP was observed in insulin-resistant subjects than in insulin-sensitive subjects regardless of hypertension. These data suggest that it would be sexual difference in the relationships among hyperleptinemia, hyperinsulinemia and hypertension.
ISSN:1064-1963
1525-6006
DOI:10.1081/CEH-100102673