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Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury
Objective: To evaluate microtubule-associated proteins (MAP-2), a dendritic marker of both acute damage and chronic neuronal regeneration after injury, in serum of survivors after severe TBI and examine the association with long-term outcome. Methods: Serum concentrations of MAP-2 were evaluated in...
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| Published in: | Brain injury 2012-12, Vol.26 (13-14), p.1629-1635 |
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| container_title | Brain injury |
| container_volume | 26 |
| creator | Mondello, Stefania Gabrielli, Andrea Catani, Sheila D'Ippolito, Mariagrazia Jeromin, Andreas Ciaramella, Antonio Bossù, Paola Schmid, Kara Tortella, Frank Wang, Kevin K. W. Hayes, Ronald L. Formisano, Rita |
| description | Objective: To evaluate microtubule-associated proteins (MAP-2), a dendritic marker of both acute damage and chronic neuronal regeneration after injury, in serum of survivors after severe TBI and examine the association with long-term outcome.
Methods: Serum concentrations of MAP-2 were evaluated in 16 patients with severe TBI (Glasgow Coma Scale score [GCS] ≤ 8) 6 months post-injury and in 16 controls. Physical and cognitive outcomes were assessed, using the Glasgow Outcome Scale Extended (GOSE) and Levels of Cognitive Functioning Scale (LCFS), respectively.
Results: Severe TBI patients had significantly higher serum MAP-2 concentrations than normal controls with no history of TBI (p = 0.008) at 6 months post-injury. MAP-2 levels correlated with the GOSE (r = 0.58, p = 0.02) and LCFS (r = 0.65, p = 0.007) at month 6. Significantly lower serum levels of MAP-2 were observed in patients in a vegetative state (VS) compared to non-VS patients (p |
| doi_str_mv | 10.3109/02699052.2012.700083 |
| format | article |
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Methods: Serum concentrations of MAP-2 were evaluated in 16 patients with severe TBI (Glasgow Coma Scale score [GCS] ≤ 8) 6 months post-injury and in 16 controls. Physical and cognitive outcomes were assessed, using the Glasgow Outcome Scale Extended (GOSE) and Levels of Cognitive Functioning Scale (LCFS), respectively.
Results: Severe TBI patients had significantly higher serum MAP-2 concentrations than normal controls with no history of TBI (p = 0.008) at 6 months post-injury. MAP-2 levels correlated with the GOSE (r = 0.58, p = 0.02) and LCFS (r = 0.65, p = 0.007) at month 6. Significantly lower serum levels of MAP-2 were observed in patients in a vegetative state (VS) compared to non-VS patients (p < 0.05). A trend tracking the level of consciousness was observed.
Conclusions: Severe TBI results in a chronic release of MAP-2 into the peripheral circulation in patients with higher levels of consciousness, suggesting that remodelling of synaptic junctions and neuroplasticity processes occur several months after injury. The data indicate MAP-2 as a potential marker for emergence to higher levels of cognitive function.</description><identifier>ISSN: 0269-9052</identifier><identifier>EISSN: 1362-301X</identifier><identifier>DOI: 10.3109/02699052.2012.700083</identifier><identifier>PMID: 22794497</identifier><language>eng</language><publisher>England: Informa UK, Ltd</publisher><subject>Adolescent ; Adult ; Aged ; biomarkers ; Biomarkers - blood ; Brain Injuries - blood ; Brain Injuries - epidemiology ; Brain Injuries - physiopathology ; cognitive functioning ; Disability Evaluation ; Female ; Follow-Up Studies ; Glasgow Outcome Scale ; Humans ; Male ; MAP2 ; Microtubule-Associated Proteins - blood ; Middle Aged ; outcome ; Persistent Vegetative State - blood ; Persistent Vegetative State - epidemiology ; Persistent Vegetative State - physiopathology ; Pilot Projects ; Prognosis ; Recovery of Function ; Survivors ; Time Factors ; traumatic brain injury ; United States - epidemiology ; Young Adult</subject><ispartof>Brain injury, 2012-12, Vol.26 (13-14), p.1629-1635</ispartof><rights>2012 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-c25cf49b399e8628d7e5908f445068632fb2c8b1b2cc349f1c57ece97fbdf1bf3</citedby><cites>FETCH-LOGICAL-c418t-c25cf49b399e8628d7e5908f445068632fb2c8b1b2cc349f1c57ece97fbdf1bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22794497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mondello, Stefania</creatorcontrib><creatorcontrib>Gabrielli, Andrea</creatorcontrib><creatorcontrib>Catani, Sheila</creatorcontrib><creatorcontrib>D'Ippolito, Mariagrazia</creatorcontrib><creatorcontrib>Jeromin, Andreas</creatorcontrib><creatorcontrib>Ciaramella, Antonio</creatorcontrib><creatorcontrib>Bossù, Paola</creatorcontrib><creatorcontrib>Schmid, Kara</creatorcontrib><creatorcontrib>Tortella, Frank</creatorcontrib><creatorcontrib>Wang, Kevin K. W.</creatorcontrib><creatorcontrib>Hayes, Ronald L.</creatorcontrib><creatorcontrib>Formisano, Rita</creatorcontrib><title>Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury</title><title>Brain injury</title><addtitle>Brain Inj</addtitle><description>Objective: To evaluate microtubule-associated proteins (MAP-2), a dendritic marker of both acute damage and chronic neuronal regeneration after injury, in serum of survivors after severe TBI and examine the association with long-term outcome.
Methods: Serum concentrations of MAP-2 were evaluated in 16 patients with severe TBI (Glasgow Coma Scale score [GCS] ≤ 8) 6 months post-injury and in 16 controls. Physical and cognitive outcomes were assessed, using the Glasgow Outcome Scale Extended (GOSE) and Levels of Cognitive Functioning Scale (LCFS), respectively.
Results: Severe TBI patients had significantly higher serum MAP-2 concentrations than normal controls with no history of TBI (p = 0.008) at 6 months post-injury. MAP-2 levels correlated with the GOSE (r = 0.58, p = 0.02) and LCFS (r = 0.65, p = 0.007) at month 6. Significantly lower serum levels of MAP-2 were observed in patients in a vegetative state (VS) compared to non-VS patients (p < 0.05). A trend tracking the level of consciousness was observed.
Conclusions: Severe TBI results in a chronic release of MAP-2 into the peripheral circulation in patients with higher levels of consciousness, suggesting that remodelling of synaptic junctions and neuroplasticity processes occur several months after injury. The data indicate MAP-2 as a potential marker for emergence to higher levels of cognitive function.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>biomarkers</subject><subject>Biomarkers - blood</subject><subject>Brain Injuries - blood</subject><subject>Brain Injuries - epidemiology</subject><subject>Brain Injuries - physiopathology</subject><subject>cognitive functioning</subject><subject>Disability Evaluation</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glasgow Outcome Scale</subject><subject>Humans</subject><subject>Male</subject><subject>MAP2</subject><subject>Microtubule-Associated Proteins - blood</subject><subject>Middle Aged</subject><subject>outcome</subject><subject>Persistent Vegetative State - blood</subject><subject>Persistent Vegetative State - epidemiology</subject><subject>Persistent Vegetative State - physiopathology</subject><subject>Pilot Projects</subject><subject>Prognosis</subject><subject>Recovery of Function</subject><subject>Survivors</subject><subject>Time Factors</subject><subject>traumatic brain injury</subject><subject>United States - epidemiology</subject><subject>Young Adult</subject><issn>0269-9052</issn><issn>1362-301X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kE1v1DAQhi1ERZfCP0DIRy5Z_JUPX0BV1ZZKreAAEjfLccZar5K4jJ1U--9JtFskLr3MXJ73ndFDyAfOtpIz_ZmJSmtWiq1gXGxrxlgjX5ENl5UoJOO_X5PNihQrc07eprRfEF5y9oacC1FrpXS9IYe70SHYBB3tYYY-0ehpApwG-nD5oxDUZloVQxzzLlEXEaG3GehTyDsahkeM85KMU3ZxABpGmiacwxzx1DMDAs1op8Hm4GiLdmHCuJ_w8I6cedsneH_aF-TXzfXPq2_F_ffbu6vL-8Ip3uTCidJ5pVupNTSVaLoaSs0ar1TJqqaSwrfCNS1fppNKe-7KGhzo2red562XF-TTsXd59s8EKZshJAd9b0eIUzKc17rkSki1oOqIOowpIXjziGGweDCcmVW6eZZuVunmKH2JfTxdmNoBun-hZ8sL8PUIhNFHHOxTxL4z2R76iB7t6EJa61888eW_hh3YPu-cRTD7OOG4CHz5x7952KXJ</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Mondello, Stefania</creator><creator>Gabrielli, Andrea</creator><creator>Catani, Sheila</creator><creator>D'Ippolito, Mariagrazia</creator><creator>Jeromin, Andreas</creator><creator>Ciaramella, Antonio</creator><creator>Bossù, Paola</creator><creator>Schmid, Kara</creator><creator>Tortella, Frank</creator><creator>Wang, Kevin K. W.</creator><creator>Hayes, Ronald L.</creator><creator>Formisano, Rita</creator><general>Informa UK, Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121201</creationdate><title>Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury</title><author>Mondello, Stefania ; Gabrielli, Andrea ; Catani, Sheila ; D'Ippolito, Mariagrazia ; Jeromin, Andreas ; Ciaramella, Antonio ; Bossù, Paola ; Schmid, Kara ; Tortella, Frank ; Wang, Kevin K. W. ; Hayes, Ronald L. ; Formisano, Rita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-c25cf49b399e8628d7e5908f445068632fb2c8b1b2cc349f1c57ece97fbdf1bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>biomarkers</topic><topic>Biomarkers - blood</topic><topic>Brain Injuries - blood</topic><topic>Brain Injuries - epidemiology</topic><topic>Brain Injuries - physiopathology</topic><topic>cognitive functioning</topic><topic>Disability Evaluation</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glasgow Outcome Scale</topic><topic>Humans</topic><topic>Male</topic><topic>MAP2</topic><topic>Microtubule-Associated Proteins - blood</topic><topic>Middle Aged</topic><topic>outcome</topic><topic>Persistent Vegetative State - blood</topic><topic>Persistent Vegetative State - epidemiology</topic><topic>Persistent Vegetative State - physiopathology</topic><topic>Pilot Projects</topic><topic>Prognosis</topic><topic>Recovery of Function</topic><topic>Survivors</topic><topic>Time Factors</topic><topic>traumatic brain injury</topic><topic>United States - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mondello, Stefania</creatorcontrib><creatorcontrib>Gabrielli, Andrea</creatorcontrib><creatorcontrib>Catani, Sheila</creatorcontrib><creatorcontrib>D'Ippolito, Mariagrazia</creatorcontrib><creatorcontrib>Jeromin, Andreas</creatorcontrib><creatorcontrib>Ciaramella, Antonio</creatorcontrib><creatorcontrib>Bossù, Paola</creatorcontrib><creatorcontrib>Schmid, Kara</creatorcontrib><creatorcontrib>Tortella, Frank</creatorcontrib><creatorcontrib>Wang, Kevin K. W.</creatorcontrib><creatorcontrib>Hayes, Ronald L.</creatorcontrib><creatorcontrib>Formisano, Rita</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain injury</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mondello, Stefania</au><au>Gabrielli, Andrea</au><au>Catani, Sheila</au><au>D'Ippolito, Mariagrazia</au><au>Jeromin, Andreas</au><au>Ciaramella, Antonio</au><au>Bossù, Paola</au><au>Schmid, Kara</au><au>Tortella, Frank</au><au>Wang, Kevin K. W.</au><au>Hayes, Ronald L.</au><au>Formisano, Rita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury</atitle><jtitle>Brain injury</jtitle><addtitle>Brain Inj</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>26</volume><issue>13-14</issue><spage>1629</spage><epage>1635</epage><pages>1629-1635</pages><issn>0269-9052</issn><eissn>1362-301X</eissn><abstract>Objective: To evaluate microtubule-associated proteins (MAP-2), a dendritic marker of both acute damage and chronic neuronal regeneration after injury, in serum of survivors after severe TBI and examine the association with long-term outcome.
Methods: Serum concentrations of MAP-2 were evaluated in 16 patients with severe TBI (Glasgow Coma Scale score [GCS] ≤ 8) 6 months post-injury and in 16 controls. Physical and cognitive outcomes were assessed, using the Glasgow Outcome Scale Extended (GOSE) and Levels of Cognitive Functioning Scale (LCFS), respectively.
Results: Severe TBI patients had significantly higher serum MAP-2 concentrations than normal controls with no history of TBI (p = 0.008) at 6 months post-injury. MAP-2 levels correlated with the GOSE (r = 0.58, p = 0.02) and LCFS (r = 0.65, p = 0.007) at month 6. Significantly lower serum levels of MAP-2 were observed in patients in a vegetative state (VS) compared to non-VS patients (p < 0.05). A trend tracking the level of consciousness was observed.
Conclusions: Severe TBI results in a chronic release of MAP-2 into the peripheral circulation in patients with higher levels of consciousness, suggesting that remodelling of synaptic junctions and neuroplasticity processes occur several months after injury. The data indicate MAP-2 as a potential marker for emergence to higher levels of cognitive function.</abstract><cop>England</cop><pub>Informa UK, Ltd</pub><pmid>22794497</pmid><doi>10.3109/02699052.2012.700083</doi><tpages>7</tpages></addata></record> |
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| ispartof | Brain injury, 2012-12, Vol.26 (13-14), p.1629-1635 |
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| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Adolescent Adult Aged biomarkers Biomarkers - blood Brain Injuries - blood Brain Injuries - epidemiology Brain Injuries - physiopathology cognitive functioning Disability Evaluation Female Follow-Up Studies Glasgow Outcome Scale Humans Male MAP2 Microtubule-Associated Proteins - blood Middle Aged outcome Persistent Vegetative State - blood Persistent Vegetative State - epidemiology Persistent Vegetative State - physiopathology Pilot Projects Prognosis Recovery of Function Survivors Time Factors traumatic brain injury United States - epidemiology Young Adult |
| title | Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury |
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