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Comparison of PLGA and lecithin/chitosan nanoparticles for dermal targeting of betamethasone valerate
Abstract Poly(lactide-co-glycolide) (PLGA) and lecithin/chitosan (LC) nanoparticles were prepared to evaluate the difference in the behavior upon administration on skin, for steroidal treatment. For this purpose, betamethasone-17-valerate (BMV)-loaded nanoparticles with a narrow size distribution an...
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| Published in: | Journal of drug targeting 2013-07, Vol.21 (6), p.542-550 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c418t-b520b8a60ccfbcf8f26d3e84081b68e45550b01631462e40cf3c2b7ab1bf9d243 |
| container_end_page | 550 |
| container_issue | 6 |
| container_start_page | 542 |
| container_title | Journal of drug targeting |
| container_volume | 21 |
| creator | Özcan, pek Azizo lu, Erkan enyi it, Taner Özyaz c, Mine Özer, Özgen |
| description | Abstract
Poly(lactide-co-glycolide) (PLGA) and lecithin/chitosan (LC) nanoparticles were prepared to evaluate the difference in the behavior upon administration on skin, for steroidal treatment. For this purpose, betamethasone-17-valerate (BMV)-loaded nanoparticles with a narrow size distribution and high entrapment efficiency were prepared. Permeation studies showed that both polymeric nanoparticles enhanced the amount of BMV in epidermis, which is the target site of topical steroidal treatment, when compared with commercial formulation. 1.58-Fold increase was determined in the epidermis concentration of BMV by LC nanoparticles with respect to PLGA nanoparticles. Nanoparticles were diluted in chitosan gel (10%, w/w) to prepare suitable formulation for topical application. Accumulation from both gel formulations were found significantly higher than commercial formulation in skin layers (p |
| doi_str_mv | 10.3109/1061186X.2013.769106 |
| format | article |
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Poly(lactide-co-glycolide) (PLGA) and lecithin/chitosan (LC) nanoparticles were prepared to evaluate the difference in the behavior upon administration on skin, for steroidal treatment. For this purpose, betamethasone-17-valerate (BMV)-loaded nanoparticles with a narrow size distribution and high entrapment efficiency were prepared. Permeation studies showed that both polymeric nanoparticles enhanced the amount of BMV in epidermis, which is the target site of topical steroidal treatment, when compared with commercial formulation. 1.58-Fold increase was determined in the epidermis concentration of BMV by LC nanoparticles with respect to PLGA nanoparticles. Nanoparticles were diluted in chitosan gel (10%, w/w) to prepare suitable formulation for topical application. Accumulation from both gel formulations were found significantly higher than commercial formulation in skin layers (p < 0.05). In addition, pharmacodynamic responses were also investigated as anti-inflammatory and skin-blanching parameters. Both formulations significantly improved these parameters although they contained 10 times less amount of BMV than commercial cream. Moreover, TEWL measurement exhibited no barrier function changes upon the application of nanoparticles on skin. Overall, both nanoparticles improved the localization of BMV within skin layers; but when compared with PLGA nanoparticles, the LC nanoparticles could be classified as a better candidate for topical delivery vehicle in the treatment of various dermatological inflammatory diseases.</description><identifier>ISSN: 1061-186X</identifier><identifier>EISSN: 1029-2330</identifier><identifier>DOI: 10.3109/1061186X.2013.769106</identifier><identifier>PMID: 23390922</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject><![CDATA[Administration, Cutaneous ; Animals ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - chemistry ; Betamethasone valerate ; Betamethasone Valerate - administration & dosage ; Betamethasone Valerate - chemistry ; Betamethasone Valerate - pharmacokinetics ; Chemistry, Pharmaceutical - methods ; Chitosan - administration & dosage ; Chitosan - chemistry ; Chitosan - pharmacokinetics ; Dermis - drug effects ; Dermis - metabolism ; Drug Delivery Systems - methods ; Epidermis - drug effects ; Epidermis - metabolism ; in-vivo evaluation ; Lactic Acid - administration & dosage ; Lactic Acid - chemistry ; lecithin/chitosan nanoparticles ; Lecithins - administration & dosage ; Lecithins - chemistry ; Lecithins - pharmacokinetics ; Male ; Nanoparticles - administration & dosage ; Nanoparticles - chemistry ; Nanoparticles - metabolism ; Particle Size ; Permeability - drug effects ; PLGA nanoparticles ; Polyglycolic Acid - administration & dosage ; Polyglycolic Acid - chemistry ; Rats ; Rats, Wistar ; Skin Absorption - drug effects ; skin permeation]]></subject><ispartof>Journal of drug targeting, 2013-07, Vol.21 (6), p.542-550</ispartof><rights>2013 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-b520b8a60ccfbcf8f26d3e84081b68e45550b01631462e40cf3c2b7ab1bf9d243</citedby><cites>FETCH-LOGICAL-c418t-b520b8a60ccfbcf8f26d3e84081b68e45550b01631462e40cf3c2b7ab1bf9d243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23390922$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Özcan, pek</creatorcontrib><creatorcontrib>Azizo lu, Erkan</creatorcontrib><creatorcontrib>enyi it, Taner</creatorcontrib><creatorcontrib>Özyaz c, Mine</creatorcontrib><creatorcontrib>Özer, Özgen</creatorcontrib><title>Comparison of PLGA and lecithin/chitosan nanoparticles for dermal targeting of betamethasone valerate</title><title>Journal of drug targeting</title><addtitle>J Drug Target</addtitle><description>Abstract
Poly(lactide-co-glycolide) (PLGA) and lecithin/chitosan (LC) nanoparticles were prepared to evaluate the difference in the behavior upon administration on skin, for steroidal treatment. For this purpose, betamethasone-17-valerate (BMV)-loaded nanoparticles with a narrow size distribution and high entrapment efficiency were prepared. Permeation studies showed that both polymeric nanoparticles enhanced the amount of BMV in epidermis, which is the target site of topical steroidal treatment, when compared with commercial formulation. 1.58-Fold increase was determined in the epidermis concentration of BMV by LC nanoparticles with respect to PLGA nanoparticles. Nanoparticles were diluted in chitosan gel (10%, w/w) to prepare suitable formulation for topical application. Accumulation from both gel formulations were found significantly higher than commercial formulation in skin layers (p < 0.05). In addition, pharmacodynamic responses were also investigated as anti-inflammatory and skin-blanching parameters. Both formulations significantly improved these parameters although they contained 10 times less amount of BMV than commercial cream. Moreover, TEWL measurement exhibited no barrier function changes upon the application of nanoparticles on skin. Overall, both nanoparticles improved the localization of BMV within skin layers; but when compared with PLGA nanoparticles, the LC nanoparticles could be classified as a better candidate for topical delivery vehicle in the treatment of various dermatological inflammatory diseases.</description><subject>Administration, Cutaneous</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Betamethasone valerate</subject><subject>Betamethasone Valerate - administration & dosage</subject><subject>Betamethasone Valerate - chemistry</subject><subject>Betamethasone Valerate - pharmacokinetics</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Chitosan - administration & dosage</subject><subject>Chitosan - chemistry</subject><subject>Chitosan - pharmacokinetics</subject><subject>Dermis - drug effects</subject><subject>Dermis - metabolism</subject><subject>Drug Delivery Systems - methods</subject><subject>Epidermis - drug effects</subject><subject>Epidermis - metabolism</subject><subject>in-vivo evaluation</subject><subject>Lactic Acid - administration & dosage</subject><subject>Lactic Acid - chemistry</subject><subject>lecithin/chitosan nanoparticles</subject><subject>Lecithins - administration & dosage</subject><subject>Lecithins - chemistry</subject><subject>Lecithins - pharmacokinetics</subject><subject>Male</subject><subject>Nanoparticles - administration & dosage</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - metabolism</subject><subject>Particle Size</subject><subject>Permeability - drug effects</subject><subject>PLGA nanoparticles</subject><subject>Polyglycolic Acid - administration & dosage</subject><subject>Polyglycolic Acid - chemistry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Skin Absorption - drug effects</subject><subject>skin permeation</subject><issn>1061-186X</issn><issn>1029-2330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kE1v1DAQhiMEoh_wDxDykUu2_kjc5AKqVtAirQQHkLhZY2fcuHLsxfYW9d_jaFskLj155HnmndHTNO8Y3QhGxwtGJWOD_LXhlInNpRzrx4vmlFE-tlwI-nKtJWtX5qQ5y_mOVlAy-ro5qf2RjpyfNriNyx6SyzGQaMn33fUVgTARj8aV2YULM7sSMwQSIMRKFmc8ZmJjIhOmBTwpkG6xuHC7BmgssGCZoQYiuQePCQq-aV5Z8BnfPr7nzc8vn39sb9rdt-uv26tdazo2lFb3nOoBJDXGamMHy-UkcOjowLQcsOv7nmrKpGCd5NhRY4Xh-hI003aceCfOmw_H3H2Kvw-Yi1pcNug9BIyHrJgYGKNU9rKi3RE1Keac0Kp9cgukB8WoWgWrJ8FqFayOguvY-8cNB73g9G_oyWgFPh0BF6qjBf7E5CdV4MHHZBME4_Ia_-yKj_8lzAi-zAYSqrt4SKEKfP7Gv1wgnvM</recordid><startdate>201307</startdate><enddate>201307</enddate><creator>Özcan, pek</creator><creator>Azizo lu, Erkan</creator><creator>enyi it, Taner</creator><creator>Özyaz c, Mine</creator><creator>Özer, Özgen</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201307</creationdate><title>Comparison of PLGA and lecithin/chitosan nanoparticles for dermal targeting of betamethasone valerate</title><author>Özcan, pek ; Azizo lu, Erkan ; enyi it, Taner ; Özyaz c, Mine ; Özer, Özgen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-b520b8a60ccfbcf8f26d3e84081b68e45550b01631462e40cf3c2b7ab1bf9d243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Administration, Cutaneous</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>Anti-Inflammatory Agents - chemistry</topic><topic>Betamethasone valerate</topic><topic>Betamethasone Valerate - administration & dosage</topic><topic>Betamethasone Valerate - chemistry</topic><topic>Betamethasone Valerate - pharmacokinetics</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Chitosan - administration & dosage</topic><topic>Chitosan - chemistry</topic><topic>Chitosan - pharmacokinetics</topic><topic>Dermis - drug effects</topic><topic>Dermis - metabolism</topic><topic>Drug Delivery Systems - methods</topic><topic>Epidermis - drug effects</topic><topic>Epidermis - metabolism</topic><topic>in-vivo evaluation</topic><topic>Lactic Acid - administration & dosage</topic><topic>Lactic Acid - chemistry</topic><topic>lecithin/chitosan nanoparticles</topic><topic>Lecithins - administration & dosage</topic><topic>Lecithins - chemistry</topic><topic>Lecithins - pharmacokinetics</topic><topic>Male</topic><topic>Nanoparticles - administration & dosage</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - metabolism</topic><topic>Particle Size</topic><topic>Permeability - drug effects</topic><topic>PLGA nanoparticles</topic><topic>Polyglycolic Acid - administration & dosage</topic><topic>Polyglycolic Acid - chemistry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Skin Absorption - drug effects</topic><topic>skin permeation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Özcan, pek</creatorcontrib><creatorcontrib>Azizo lu, Erkan</creatorcontrib><creatorcontrib>enyi it, Taner</creatorcontrib><creatorcontrib>Özyaz c, Mine</creatorcontrib><creatorcontrib>Özer, Özgen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of drug targeting</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Özcan, pek</au><au>Azizo lu, Erkan</au><au>enyi it, Taner</au><au>Özyaz c, Mine</au><au>Özer, Özgen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of PLGA and lecithin/chitosan nanoparticles for dermal targeting of betamethasone valerate</atitle><jtitle>Journal of drug targeting</jtitle><addtitle>J Drug Target</addtitle><date>2013-07</date><risdate>2013</risdate><volume>21</volume><issue>6</issue><spage>542</spage><epage>550</epage><pages>542-550</pages><issn>1061-186X</issn><eissn>1029-2330</eissn><abstract>Abstract
Poly(lactide-co-glycolide) (PLGA) and lecithin/chitosan (LC) nanoparticles were prepared to evaluate the difference in the behavior upon administration on skin, for steroidal treatment. For this purpose, betamethasone-17-valerate (BMV)-loaded nanoparticles with a narrow size distribution and high entrapment efficiency were prepared. Permeation studies showed that both polymeric nanoparticles enhanced the amount of BMV in epidermis, which is the target site of topical steroidal treatment, when compared with commercial formulation. 1.58-Fold increase was determined in the epidermis concentration of BMV by LC nanoparticles with respect to PLGA nanoparticles. Nanoparticles were diluted in chitosan gel (10%, w/w) to prepare suitable formulation for topical application. Accumulation from both gel formulations were found significantly higher than commercial formulation in skin layers (p < 0.05). In addition, pharmacodynamic responses were also investigated as anti-inflammatory and skin-blanching parameters. Both formulations significantly improved these parameters although they contained 10 times less amount of BMV than commercial cream. Moreover, TEWL measurement exhibited no barrier function changes upon the application of nanoparticles on skin. Overall, both nanoparticles improved the localization of BMV within skin layers; but when compared with PLGA nanoparticles, the LC nanoparticles could be classified as a better candidate for topical delivery vehicle in the treatment of various dermatological inflammatory diseases.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>23390922</pmid><doi>10.3109/1061186X.2013.769106</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1061-186X |
| ispartof | Journal of drug targeting, 2013-07, Vol.21 (6), p.542-550 |
| issn | 1061-186X 1029-2330 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_3109_1061186X_2013_769106 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Administration, Cutaneous Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - chemistry Betamethasone valerate Betamethasone Valerate - administration & dosage Betamethasone Valerate - chemistry Betamethasone Valerate - pharmacokinetics Chemistry, Pharmaceutical - methods Chitosan - administration & dosage Chitosan - chemistry Chitosan - pharmacokinetics Dermis - drug effects Dermis - metabolism Drug Delivery Systems - methods Epidermis - drug effects Epidermis - metabolism in-vivo evaluation Lactic Acid - administration & dosage Lactic Acid - chemistry lecithin/chitosan nanoparticles Lecithins - administration & dosage Lecithins - chemistry Lecithins - pharmacokinetics Male Nanoparticles - administration & dosage Nanoparticles - chemistry Nanoparticles - metabolism Particle Size Permeability - drug effects PLGA nanoparticles Polyglycolic Acid - administration & dosage Polyglycolic Acid - chemistry Rats Rats, Wistar Skin Absorption - drug effects skin permeation |
| title | Comparison of PLGA and lecithin/chitosan nanoparticles for dermal targeting of betamethasone valerate |
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