Outcome of singleton preterm small for gestational age infants born to mothers with pregnancy-induced hypertension. A population-based study

• Published in: The journal of maternal-fetal & neonatal medicine 2015-04, Vol.28 (6), p.666-673
• Main Authors: Regev, Rivka H., Arnon, Shmuel, Litmanovitz, Ita, Bauer-Rusek, Sofia, Boyko, Valentina, Lerner-Geva, Liat, Reichman, Brian
• Format: Article
• Language: English
• Subjects: Acute pregnancy complications; Adolescent; Adult; Female; Humans; Hypertension, Pregnancy-Induced - diagnosis; Hypertension, Pregnancy-Induced - epidemiology; Infant; Infant Mortality; Infant, Extremely Premature; Infant, Newborn; Infant, Small for Gestational Age; Infant, Very Low Birth Weight; Israel - epidemiology; Male; Mothers; outcome; Pregnancy; Pregnancy Outcome - epidemiology; pregnancy-induced hypertension; premature infants; Prognosis; small for gestational age; very-low-birth-weight; Young Adult
• ISSN: 1476-7058; 1476-4954
• DOI: 10.3109/14767058.2014.928851

Abstract Background: Pregnancy-induced hypertension (PIH) has been associated with a decreased risk of infant mortality in small for gestational age (SGA) preterm infants. Objective: To evaluate the influence of PIH on mortality and major neonatal morbidities in singleton preterm SGA infants, in the presence and absence of acute pregnancy complications. Methods: Population-based observational study of singleton SGA infants, born at 24 to 32 weeks gestation in the period 1995-2010 (n = 2139). Multivariable logistic regression analyses were used to assess the independent effect of PIH on mortality and neonatal morbidities. Acute pregnancy complications comprised premature labor, premature rupture of membranes >6 h, antepartum hemorrhage and clinical chorioamnionitis. Results: In the absence of pregnancy complications, the odds ratio (95% confidence interval) for mortality (0.77; 0.50-1.16), survival without severe neurological morbidity (1.14; 0.79-1.65) and survival without bronchopulmonary dysplasia (BPD) (0.85; 0.59-1.21) were similar in the PIH versus no-PIH groups. In the presence of pregnancy complications, mortality (0.76; 0.40-1.44), survival without severe neurological morbidity (1.16; 0.64-2.12) and survival without BPD (1.04; 0.58-1.86) were also similar in the PIH versus no-PIH groups. Conclusions: PIH was not associated with improved outcome in preterm SGA infants, both in the presence and absence of acute pregnancy complications.