Association of Helicobacter pylori and Epstein-Barr virus with gastric cancer and peptic ulcer disease

Objective. Helicobacter pylori and Epstein-Barr virus (EBV) infections are common world-wide. Though H. pylori infection is a major factor in gastroduodenal diseases, its role in association with EBV infection is unknown. We prospectively studied the association of H. pylori and EBV in patients with...

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Published in:Scandinavian journal of gastroenterology 2008, Vol.43 (6), p.669-674
Main Authors: Saxena, Ashish, Nath Prasad, Kashi, Chand Ghoshal, Uday, Krishnani, Narendra, Roshan Bhagat, Monty, Husain, Nuzhat
Format: Article
Language:English
Subjects:
Adult
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
DNA, Viral - analysis
Dyspepsia
Epstein-Barr Virus Infections - complications
Female
gastric cancer
Gastroenterology. Liver. Pancreas. Abdomen
Helicobacter Infections - complications
Helicobacter pylori - isolation & purification
Herpesvirus 4, Human - isolation & purification
Human bacterial diseases
Humans
Infectious diseases
Male
Medical sciences
Middle Aged
Other diseases. Semiology
pathogenesis
PCR
peptic ulcer
Peptic Ulcer - microbiology
Peptic Ulcer - virology
Stomach Neoplasms - microbiology
Stomach Neoplasms - virology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:Objective. Helicobacter pylori and Epstein-Barr virus (EBV) infections are common world-wide. Though H. pylori infection is a major factor in gastroduodenal diseases, its role in association with EBV infection is unknown. We prospectively studied the association of H. pylori and EBV in patients with gastric cancer (GC) and peptic ulcer disease (PUD). Material and methods. A total of 348 adult patients (non-ulcer dyspepsia (NUD) 241, PUD 45, GC 62) undergoing upper gastrointestinal endoscopy between September 2003 and May 2007 were enrolled in the study. H. pylori infection was diagnosed by rapid urease test, culture, histopathology and polymerase chain reaction (PCR). EBV DNA was detected by non-polymorphic Epstein-Barr nuclear antigen-1 (EBNA-1) gene-based PCR and sequence analysis. Results. The rate of H. pylori infection was higher in patients with PUD than in those with GC (80% versus 56.5%, p=0.01) and NUD (80% versus 55.2%, p=0.002). In patients with GC and PUD, EBV DNA was detected more often than in those with NUD (GC versus NUD - 82.3% versus 37.3%, p
ISSN:0036-5521
1502-7708
DOI:10.1080/00365520801909660