NovaSil clay intervention in Ghanaians at high risk for aflatoxicosis: II. Reduction in biomarkers of aflatoxin exposure in blood and urine

• Published in: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Chemistry, analysis, control, exposure & risk assessment, 2008-05, Vol.25 (5), p.622-634
• Main Authors: Wang, P., Afriyie-gyawu, E., Tang, Y., Johnson, N. M., Xu, L., Tang, L., Huebner, H. J., Ankrah, N.-A., Ofori-adjei, D., Ellis, W., Jolly, P. E., Williams, J. H., Wang, J.-S., Phillips, T. D.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; aflatoxicosis; Aflatoxins - blood; Aflatoxins - poisoning; Aflatoxins - urine; Aluminum Silicates - administration & dosage; biomarkers; Biomarkers - blood; Biomarkers - urine; Double-Blind Method; Food Additives - administration & dosage; fungal metabolites; Ghana; Humans; Male; Middle Aged; NovaSil clay; Risk Factors; Statistics as Topic
• ISSN: 1944-0049; 1944-0057
• DOI: 10.1080/02652030701598694

The efficacy of NovaSil clay (NS) to reduce aflatoxin (AF) biomarkers of exposure was evaluated in 656 blood samples and 624 urine samples collected from study participants during a 3-month phase IIa clinical intervention trial in Ghana. NS was delivered before meals via capsules. Serum AFB 1 -albumin adduct was measured by radioimmunoassay and urinary AFM 1 metabolites were quantified by immunoaffinity-high-performance liquid chromatography (HPLC)-fluorescence methods. Levels of AFB 1 -albumin adduct in serum samples collected at baseline and at 1 month were similar (p = 0.2354 and p = 0.3645, respectively) among the placebo (PL), low dose (LD, 1.5 g NS day −1 ), and high dose (HD, 3.0 g NS day −1 ) groups. However, the levels of AFB 1 -albumin adduct at 3 months were significantly decreased in both the LD group (p