Detection of Torque teno virus in Epstein-Barr virus positive and negative lymph nodes of patients with Hodgkin lymphoma

The age-specific incidence of Hodgkin lymphoma (HL) is bimodal with peaks occurring among young adults (15 - 34 years old) and people older than 45 years. Epstein-Barr virus (EBV) is associated with only one-third of HL cases. This study sought to determine if Torque teno virus (TTV) might be indepe...

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Bibliographic Details
Published in:Leukemia & lymphoma 2007-01, Vol.48 (4), p.731-735
Main Authors: Figueiredo, Claudia P., Franz-Vasconcelos, Helena C. F., di Giunta, Gabriella, Mazzuco, Tania L., Caon, Thiago, Fernandes, André L. M., Simões, Cláudia M. O., Antunes, Victor L. S., Niel, Christian, Barardi, Célia R. M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Brazil
Child
Child, Preschool
DNA Virus Infections - complications
Epstein-Barr virus
Epstein-Barr Virus Infections - complications
Female
Herpesvirus 4, Human - metabolism
Hodgkin Disease - pathology
Hodgkin Disease - virology
Hodgkin lymphoma
Humans
lymph nodes
Lymph Nodes - virology
Male
Middle Aged
Torque teno virus
Torque teno virus - metabolism
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Summary:The age-specific incidence of Hodgkin lymphoma (HL) is bimodal with peaks occurring among young adults (15 - 34 years old) and people older than 45 years. Epstein-Barr virus (EBV) is associated with only one-third of HL cases. This study sought to determine if Torque teno virus (TTV) might be independently associated with HL. The presence of EBV was appraised by in situ hybridization and immunohistochemistry in lymph node biopsies from 46 patients (3 - 81 years old) with HL. TTV DNA was assessed by PCR amplification. EBV was detected in 22 (48%) patients. TTV DNA was detected in 24 46 (52%) patients, as well as in 12 20 (60%) control patients with lymphoid unspecific hyperplasia. TTV DNA was not significantly more frequent in EBV negative (54%) than in EBV positive (50%) nodes. However, it was observed that the group of young adults (15 - 34 years, n = 19) showed the lowest EBV frequency (21%) but the highest TTV occurrence (60%). This may suggest an involvement of TTV infection in the pathogenesis of HL in young adults. Further large population-based studies are required to confirm our findings.
ISSN:1042-8194
1029-2403
DOI:10.1080/10428190701203954