Suppression of cell attachment and protein adsorption onto amphiphilic polylactide-grafted dextran films

To develop novel biodegradable biomedical materials, polylactide-grafted dextrans (Dexg-PLA)s having various lengths, numbers of graft chains and sugar units were synthesized using the trimethylsilyl (TMS) protection method. To explore the possibility of using Dex-g-PLA as a biomedical soft-material...

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Bibliographic Details
Published in:Journal of biomaterials science. Polymer ed. 2005-01, Vol.16 (8), p.1035-1045
Main Authors: Ouchi, Tatsuro, Kontani, Tomohiro, Saito, Toshifumi, Ohya, Yuichi
Format: Article
Language:English
Subjects:
Adsorption
Animals
BIODEGRADABLE POLYMER
Cattle
Cell Adhesion
CELL ATTACHMENT
Cell Line
DEXTRAN
Dextrans - chemistry
Mice
Microscopy, Electron, Scanning
Molecular Structure
Polyesters - chemistry
POLYLACTIDE
PROTEIN ADSORPTION
Serum Albumin - chemistry
Temperature
Water - chemistry
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Summary:To develop novel biodegradable biomedical materials, polylactide-grafted dextrans (Dexg-PLA)s having various lengths, numbers of graft chains and sugar units were synthesized using the trimethylsilyl (TMS) protection method. To explore the possibility of using Dex-g-PLA as a biomedical soft-material, the contact angle, cell attachment and protein adsorption properties of the films prepared from these biodegradable and amphiphilic graft co-polymers were investigated. The poly-L-lactide (PLLA) film did not absorb water at all because of its high hydrophobicity, while the graft co-polymer films started immediately to swell after immersion in PBS. The percentage of water absorption at equilibrium increased with increasing sugar unit content. The receding contact angle of the Dex-g-PLA films against water was smaller than that of the PLLA film. The receding contact angle of Dex-g-PLA films against water decreased with increasing the sugar unit content. The top surface of the Dex-g-PLA film was suggested to be covered with hydrophilic Dex segments by means of annealing in water and to afford the wettable surface. Such a wettable surface led to the suppression of cell attachment and protein adsorption onto the film.
ISSN:0920-5063
1568-5624
DOI:10.1163/1568562054414649