Kinetic Analysis for the Degradation of Glycyl-L-leucine and L-Leucyl-glycine in Subcritical Water

Two dipeptides, glycyl-L-leucine (G-L) and L-leucyl-glycine (L-G), the concentrations of which were 10 mmol/L, were degraded in subcritical water in order to understand fully the phenomena occurring during treatment. Treatment was administered in a stainless steel tubular reactor, which was connecte...

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Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2012-01, Vol.76 (1), p.125-128
Main Authors: KOBAYASHI, Takashi, FUJITA, Ryo, CHAIYAPAT, Incharoensakdi, MORI, Hajime, HOSODA, Asao, TANIGUCHI, Hisaji, ADACHI, Shuji
Format: Article
Language:English
Subjects:
Biological and medical sciences
cyclo-(glycyl-L-leucine)
degradation
dipeptide
Dipeptides - chemistry
Fundamental and applied biological sciences. Psychology
Hydrophobic and Hydrophilic Interactions
Kinetics
Models, Chemical
ring formation
subcritical water
Temperature
Thermodynamics
Water - chemistry
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Summary:Two dipeptides, glycyl-L-leucine (G-L) and L-leucyl-glycine (L-G), the concentrations of which were 10 mmol/L, were degraded in subcritical water in order to understand fully the phenomena occurring during treatment. Treatment was administered in a stainless steel tubular reactor, which was connected to an HPLC pump and immersed in an oil bath at 200-240 °C, with residence times of 10-180 s. When G-L and L-G were treated, L-G and G-L significantly formed, respectively, and then they gradually decreased at every temperature. Irrespective of the kind of substrate, ring formation occurred, and cyclo-(glycyl-L-leucine) was one of the final products. The reaction rate constants related to degradation were estimated under the assumption that all the reactions obeyed first-order kinetics, and the simulated results corresponded well with the experimental ones in every case.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.110590