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Transthyretin isoleucine-122 mutation in African and American blacks

The gene frequency of the transthyretin (TTR) mutation (Vall22Ile) was studied in African and African-American populations. The African populations analyzed included the Zulu and Xhosa of South Africa, and Yorubas from the city of Ibadan, Nigeria. The African-American population included patients at...

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Published in:	Amyloid 2000, Vol.7 (2), p.121-125
Main Authors:	Afolabi, Isaki, Asl, Kamran Hamidi, Nakamura, Masaaki, Jacobs, Peter, Hendrie, Hugh, Benson, Merrill D.
Format:	Article
Language:	English
Subjects:	Adult Africa Aged amyloidosis Black or African American Black People cardiomyopathy Female hereditary Humans Isoleucine - genetics isoleucine-122 Male Middle Aged Mutation Prealbumin - genetics transthyretin United States
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creator	Afolabi, Isaki Asl, Kamran Hamidi Nakamura, Masaaki Jacobs, Peter Hendrie, Hugh Benson, Merrill D.
description	The gene frequency of the transthyretin (TTR) mutation (Vall22Ile) was studied in African and African-American populations. The African populations analyzed included the Zulu and Xhosa of South Africa, and Yorubas from the city of Ibadan, Nigeria. The African-American population included patients at the Veterans Affairs (VA) Medical Center, Indianapolis, and newborns from a local hospital in Indianapolis. The Vall22Ile TTR mutation was identified in I of 55 Zulu, 0 of 34 Xhosa, 0 of 9 Nigerian subjects, 5 of 51 Veteran patients, and 3 of 103 newborns. Assuming the 2.91% prevalence in newborns to be the norm, there is a significant increased prevalence in the VA patient population.
doi_str_mv	10.3109/13506120009146249
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source	Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects	Adult Africa Aged amyloidosis Black or African American Black People cardiomyopathy Female hereditary Humans Isoleucine - genetics isoleucine-122 Male Middle Aged Mutation Prealbumin - genetics transthyretin United States
title	Transthyretin isoleucine-122 mutation in African and American blacks
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