Long-Term Clinical Outcomes in Diabetic Rhesus Macaques (Macaca mulatta) Treated with Medroxyprogesterone Acetate for Endometriosis

Depot medroxyprogesterone acetate (DMPA) is a common medical treatment for endometriosis in NHP. Because DMPA reportedly impairs glucoregulatory function in humans and rhesus macaques, as well as predisposes humans to diabetes mellitus (DM), we performed a retrospective study to further investigate...

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Bibliographic Details
Published in:Comparative medicine 2016-08, Vol.66 (4), p.343-348
Main Authors: Connolly, Meghan A, Trentalange, Mark, Zeiss, Caroline J
Format: Article
Language:English
Subjects:
Animals
Delayed-Action Preparations
Diabetes Complications - drug therapy
Diabetes Complications - veterinary
Endometriosis - complications
Endometriosis - drug therapy
Endometriosis - veterinary
Female
Macaca mulatta
Medroxyprogesterone Acetate - administration & dosage
Medroxyprogesterone Acetate - adverse effects
Monkey Diseases - drug therapy
Nonhuman Primate Models
Retrospective Studies
Treatment Outcome
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Summary:Depot medroxyprogesterone acetate (DMPA) is a common medical treatment for endometriosis in NHP. Because DMPA reportedly impairs glucoregulatory function in humans and rhesus macaques, as well as predisposes humans to diabetes mellitus (DM), we performed a retrospective study to further investigate its potential long-term clinical effects in animals with and without DM. Using a cohort of 29 rhesus macaques, we explored the hypotheses that DMPA treatment accelerates the onset of DM and that its use in rhesus macaques with endometriosis worsens clinical outcome measures (lifespan, body weight and body condition score). For both body weight and body condition score, a declining and statistically significant trend in mean values was evident as macaques developed either DM, or endometriosis or both. The addition of DMPA did not significantly alter this pattern. The presence of DM, endometriosis, or DMPA treatment statistically but not clinically significantly increased risk of death. Similarly, the presence of the 2 highly correlated variables endometriosis and DMPA treatment statistically but not clinically significantly increased the risk of incident DM. These results indicate that DMPA treatment was associated with worsening trends in lifespan and incident DM, however these trends did not achieve clinical significance in this cohort.
ISSN:1532-0820
2769-819X