Temporal trends in the prevalence of Mycobacterium tuberculosis infection in South African adolescents

• Published in: The international journal of tuberculosis and lung disease 2019-05, Vol.23 (5), p.571-578
• Main Authors: Bunyasi, E. W., Geldenhuys, H., Mulenga, H., Shenje, J., Luabeya, A. K. K., Tameris, M., Nemes, E., Mahomed, H., Rozot, V., Wood, R., Scriba, T., Andrews, J. R., Hatherill, M.
• Format: Article
• Language: English
• Subjects: Adolescent; Adolescents; Age Distribution; Child; Children; Cohort Studies; Epidemiology; Female; Gold; Humans; Infections; Infectious Disease; Latent Tuberculosis - diagnosis; Latent Tuberculosis - epidemiology; Latent Tuberculosis - transmission; Male; Mycobacterium tuberculosis; Prevalence; Schools; Socioeconomic Factors; Socioeconomics; South Africa - epidemiology; Teenagers; Transmission; Trends; Tuberculosis; Vaccines; Young Adult
• ISSN: 1027-3719; 1815-7920
• DOI: 10.5588/ijtld.18.0283

SETTING: South Africa.OBJECTIVE: 1) To measure changes in the adolescent prevalence of latent tuberculous infection (LTBI) between 2005 and 2015, and 2) to evaluate medium-term impact of TB control measures on LTBI prevalence.DESIGN: We compared baseline data from a cohort study (2005-2007) and a vaccine trial (2014-2015) which enrolled adolescents from the same eight South African high schools. LTBI was defined based on QuantiFERON®-TB Gold In-Tube test positivity.RESULTS: We analysed data from 4880 adolescents between 2005 and 2007, and 1968 adolescents between 2014 and 2015, when the average LTBI prevalence was respectively 43.8% (95%CI 28.4-59.1) vs. 48.5% (95%CI 41.1-55.8). Age-specific LTBI prevalence increased between the ages 12 and 18 years by 13% only in lower socio-economic quintile schools, where the average LTBI prevalence was unchanged between the two periods (54% vs. 53%). In the highest socio-economic quintile schools, LTBI prevalence did not increase with age; however, the average LTBI prevalence increased from 20% to 38% between the two periods.CONCLUSION: Adolescent LTBI prevalence remained high and constant over a decade, suggesting that Mycobacterium tuberculosis transmission to children was not impacted in the medium term by effective TB control efforts. Trends in adolescent LTBI prevalence should be interpreted in the context of the sociodemographic factors that affect the risk of transmission before and during adolescence.