Improving haemodynamic optimization of cardiac resynchronization therapy for heart failureAll work was performed at National Heart and Lung Institute, Imperial College London

Objective: Optimization of cardiac resynchronization therapy using non-invasive haemodynamic parameters produces reliable optima when performed at high atrial paced heart rates. Here we investigate whether this is a result of increased heart rate or atrial pacing itself. Approach: Forty-three patien...

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Bibliographic Details
Published in:Physiological measurement 2019-04, Vol.40 (4)
Main Authors: Sharp, Alexander J, Sohaib, S M Afzal, Shun-Shin, Matthew J, Pabari, Punam, Willson, Keith, Rajkumar, Christopher, Hughes, Alun D, Kanagaratnam, Prapa, Mayet, Jamil, Whinnett, Zachary I, Kyriacou, Andreas A, Francis, Darrel P
Format: Article
Language:English
Subjects:
atrioventricular delay
cardiac resynchronization therapy
haemodynamic optimization
heart failure
Online Access:Get full text
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Summary:Objective: Optimization of cardiac resynchronization therapy using non-invasive haemodynamic parameters produces reliable optima when performed at high atrial paced heart rates. Here we investigate whether this is a result of increased heart rate or atrial pacing itself. Approach: Forty-three patients with cardiac resynchronization therapy underwent haemodynamic optimization of atrioventricular (AV) delay using non-invasive beat-to-beat systolic blood pressure in three states: rest (atrial-sensing, 66  ±  11 bpm), slow atrial pacing (73  ±  12 bpm), and fast atrial pacing (94  ±  10 bpm). A 20-patient subset underwent a fourth optimization, during exercise (80  ±  11 bpm). Main results: Intraclass correlation coefficient (ICC, quantifying information content mean  ±SE) was 0.20  ±  0.02 for resting sensed optimization, 0.45  ±  0.03 for slow atrial pacing (p   
ISSN:0967-3334
1361-6579
DOI:10.1088/1361-6579/ab152c