Mathematical Modelling of Carbon Dioxide Exchange in Hollow Fiber Membrane Oxygenator

The main objective of this study is to simulate the carbon dioxide (CO2) blood-gas exchange in membrane oxygenator, evaluate the effect of sweep gas flow rate on CO2 partial pressure (pCO2) and to determine the response of pCO2 to the step change of sweep gas flow rate. In extension to the simulatio...

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Bibliographic Details
Published in:IOP conference series. Materials Science and Engineering 2017-06, Vol.210 (1), p.12003
Main Authors: Manap, Hany Hazfiza, Abdul Wahab, Ahmad Khairi, Zuki, Fathiah Mohamed
Format: Article
Language:English
Subjects:
Blood
Carbon dioxide
carbon dioxide removal
Carbon sequestration
Flow velocity
Gas exchange
Gas flow
Hollow fiber membranes
Mathematical analysis
mathematical modelling
Mathematical models
Membrane oxygenator
one-way ANOVA
open-loop control
Partial pressure
Simulation
Surgical apparatus & instruments
Variance analysis
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Summary:The main objective of this study is to simulate the carbon dioxide (CO2) blood-gas exchange in membrane oxygenator, evaluate the effect of sweep gas flow rate on CO2 partial pressure (pCO2) and to determine the response of pCO2 to the step change of sweep gas flow rate. In extension to the simulation of gas transfer in membrane oxygenator, open-loop response on sweep gas flow rate was applied to the developed mathematical model to prove its effect on CO2 removal rate. Three sweep gas flow rates were set, i.e. 1 L/min (Qg/Qb = 0.5), 2 L/min (Qg/Qb = 1) and 4 L/min (Qg/Qb = 2) and the simulated pCO2 in artery was observed. Next, one-way ANOVA test was performed to determine the significant difference in CO2 removal rate between these gas flow rates. For the next test, sweep gas flow rate was changed at t = 60 second and t = 120 second of simulation, to evaluate how pCO2 will response to the step change of gas flow rate. As the result, the highest CO2 removal observed when Qg/Qb = 2, as compared to gas-blood ratio of 1 and 0.5. The ANOVA test also proved the significant difference in simulated pCO2 for each flow rate. For the last test, a proportional response of pCO2 towards the change of sweep gas flow rate was highlighted. In conclusion, the rate of CO2 removal from blood can be manipulated by sweep gas flow rate and this rate can be adjusted to achieve the optimum performance of membrane oxygenator for CO2 sequestration.
ISSN:1757-8981
1757-899X
1757-899X
DOI:10.1088/1757-899X/210/1/012003