Functionalized magnetite silica thin films fabricated by MAPLE with antibiofilm properties

We report on the fabrication of magnetite salicylic acid silica shell antibiotics (Fe3O4 SA SiO2 ATB) thin films by matrix-assisted pulsed laser evaporation (MAPLE) to inert substrates. Fe3O4-based powder have been synthesized and investigated by XRD and TEM. All thin films were studied by FTIR, SEM...

Full description

Saved in:
Bibliographic Details
Published in:Biofabrication 2013-03, Vol.5 (1), p.015007-015007
Main Authors: Mihaiescu, D E, Cristescu, R, Dorcioman, G, Popescu, C E, Nita, C, Socol, G, Mihailescu, I N, Grumezescu, A M, Tamas, D, Enculescu, M, Negrea, R F, Ghica, C, Chifiriuc, C, Bleotu, C, Chrisey, D B
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
antimicrobial activity
Biofilms - drug effects
core/shell
Drug Carriers - chemical synthesis
Drug Carriers - chemistry
Drug Delivery Systems - instrumentation
Drug Delivery Systems - methods
Fe3O4/silica/antibiotic nanoparticles
Lasers
magnetic nanoparticle
Magnetite Nanoparticles - chemistry
matrix assisted pulsed laser evaporation
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - physiology
Silicon Dioxide - chemistry
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report on the fabrication of magnetite salicylic acid silica shell antibiotics (Fe3O4 SA SiO2 ATB) thin films by matrix-assisted pulsed laser evaporation (MAPLE) to inert substrates. Fe3O4-based powder have been synthesized and investigated by XRD and TEM. All thin films were studied by FTIR, SEM and in vitro biological assays using Staphylococcus aureus and Pseudomonas aeruginosa reference strains, as well as eukaryotic HEp-2 cells. The influence of the obtained nanosystems on the microbial biofilm development as well as their biocompatibility has been assessed. For optimum deposition conditions, we obtained uniform adherent films with the composition identical with the raw materials. Fe3O4 SA SiO2 ATB thin films had an inhibitory activity on the ability of microbial strains to initiate and develop mature biofilms, in a strain- and antibiotic-dependent manner. These magnetite silica thin films are promising candidates for the development of novel materials designed for the inhibition of medical biofilms formed by different pathogenic agents on common substrates, frequently implicated in the etiology of chronic and hard to treat infections.
ISSN:1758-5082
1758-5090
DOI:10.1088/1758-5082/5/1/015007